Mesoporous silica nanoparticles for drug and gene delivery
文献类型：期刊论文
| 作者 | Zhou Yixian3; Quan Guilan3; Wu Qiaoli3; Zhang Xiaoxu2; Niu Boyi3; Wu Biyuan3; Huang Ying3; Pan Xin3; Wu Chuanbin3 |
| 刊名 | Acta Pharmaceutica Sinica B
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:2页码:165 |
| 关键词 | Therapeutics. Pharmacology RM1-950 |
| ISSN号 | 2211-3835 |
| 英文摘要 | Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume, selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly, the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. KEY WORDS: Mesoporous silica nanoparticles, Poorly soluble drug, Cancer therapy, Multidrug resistance, Gene delivery |
| 资助项目 | [National Natural Science Foundation of China] ; [Natural Science Fund Project of Guangdong Province] ; [Science and Technology Plan Projects of Guangdong Province] ; [Science and Technology Foundation Guangzhou] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294646]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.青岛黄海学院 3.中国科学院广州地球化学研究所 |
| 推荐引用方式 GB/T 7714 | Zhou Yixian,Quan Guilan,Wu Qiaoli,et al. Mesoporous silica nanoparticles for drug and gene delivery[J]. Acta Pharmaceutica Sinica B,2018,8(2):165. |
| APA | Zhou Yixian.,Quan Guilan.,Wu Qiaoli.,Zhang Xiaoxu.,Niu Boyi.,...&Wu Chuanbin.(2018).Mesoporous silica nanoparticles for drug and gene delivery.Acta Pharmaceutica Sinica B,8(2),165. |
| MLA | Zhou Yixian,et al."Mesoporous silica nanoparticles for drug and gene delivery".Acta Pharmaceutica Sinica B 8.2(2018):165. |
入库方式： OAI收割
来源：上海药物研究所
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