Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro
文献类型：期刊论文
| 作者 | Wu Haoshu2; Yu Juanhong1; Li Yingyin2; Yang Yushe1 ; He Qianjun2; Lou Yijia2; Ji Ruyun1
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:3页码:417 |
| 关键词 | YY20 peroxisome proliferator-activated receptor γ insulin sensitivity glucose consumption |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY20 in insulin-sensitive cell lines. Methods: The peroxisome proliferator-activated receptor g (PPARg) agonist bioactivities of YY20 were detected by a preadipocyte differentiation assay. RT-PCR and Western blotting analysis were used to detect the expression of the target gene or protein. The effects of YY20 on insulin-mediated glucose consumption were determined in the HepG2 human hepatocellular carcinoma line. Results: YY20 could enhance the differentiation of preadipocytes to adipocytes and upregulate the gene expression of PPARg2, as well as the protein expression of insulin receptor substrate-1 (IRS-1), glucose transporter-4 (GLUT4), and adiponectin (ACRP30). The effects on GLUT4 and ACRP30 could be reversed by the PPARg inhibitor SR-202. Furthermore, YY20 efficiently reduced glucose consumptions in HepG2 cells after 24 h culture, and the effects were related to insulin and YY20 concentrations. Conclusion: YY20, a potential insulin-sensitizing agent like rosiglitazone, could enhance glucose consumption in HepG2 cells in a concentration- and insulin-dependent manner. It may improve the insulin resistance associated with type 2 diabetes. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294700]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.浙江大学 |
| 推荐引用方式 GB/T 7714 | Wu Haoshu,Yu Juanhong,Li Yingyin,et al. Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro[J]. Acta Pharmacologica Sinica,2007,28(3):417. |
| APA | Wu Haoshu.,Yu Juanhong.,Li Yingyin.,Yang Yushe.,He Qianjun.,...&Ji Ruyun.(2007).Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro.Acta Pharmacologica Sinica,28(3),417. |
| MLA | Wu Haoshu,et al."Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro".Acta Pharmacologica Sinica 28.3(2007):417. |
入库方式： OAI收割
来源：上海药物研究所
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