The role of K-opioid receptor activation in mediating antinociception and addiction
文献类型：期刊论文
| 作者 | Wang Yuhua2; Sun Jianfeng1; Tao Yimin1; Chi Zhiqiang1 ; Liu Jinggen1
|
| 刊名 | 中国药理学报：英文版
 |
| 出版日期 | 2010 |
| 卷号 | 000期号:009页码:1065 |
| 关键词 | 阿片受体 镇痛作用 调解 激活 受体激动剂 非人灵长类动物 中枢神经系统 内源性阿片肽 |
| ISSN号 | 1671-4083 |
| 英文摘要 | The K-opioid receptor （KOR）, a member of the opioid receptor family, is widely expressed in the central nervous system and peripheral tissues. Substantial evidence has shown that activation of KOR by agonists and endogenous opioid peptides in vivo may produce a strong analgesic effect that is free from the abuse potential and the adverse side effects of p-opioid receptor （MOR） agonists, such as morphine. In addition, activation of the KOR has also been shown to exert an inverse effect on morphine-induced adverse actions, such as tolerance, reward, and impairment of learning and memory. Therefore, the KOR has received much attention in the effort to develop alternative analgesics to MOR agonists and agents for the treatment of drug addiction. However, KOR agonists also produce several severe undesirable side effects such as dysphoria, water diuresis, salivation, emesis, and sedation in nonhuman primates, which may limit the clinical utility of KOR agonists for pain and drug abuse treatment. This article will review the role of KOR activation in mediating antinociception and addiction. The possible therapeutic application of K-agonists in the treatment of pain and drug addiction is also discussed. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294764]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.南京中医药大学 |
| 推荐引用方式 GB/T 7714 | Wang Yuhua,Sun Jianfeng,Tao Yimin,et al. The role of K-opioid receptor activation in mediating antinociception and addiction[J]. 中国药理学报：英文版,2010,000(009):1065. |
| APA | Wang Yuhua,Sun Jianfeng,Tao Yimin,Chi Zhiqiang,&Liu Jinggen.(2010).The role of K-opioid receptor activation in mediating antinociception and addiction.中国药理学报：英文版,000(009),1065. |
| MLA | Wang Yuhua,et al."The role of K-opioid receptor activation in mediating antinociception and addiction".中国药理学报：英文版 000.009(2010):1065. |
入库方式： OAI收割
来源：上海药物研究所
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