Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling
文献类型：期刊论文
| 作者 | Li Guofu1; Wang Kun1; Chen Rui3; Zhao Haoru2; Yang Jin3; Zheng Qingshan1 |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:11页码:1359 |
| 关键词 | TISSUE DISTRIBUTION DRUG DISCOVERY INTRASUBJECT VARIABILITY PBPK SIMULATION P-GP ABSORPTION POPULATION PREDICTION BIOAVAILABILITY IDENTIFICATION bisoprolol whole-body physiologically based pharmacokinetic model drug absorption drug distribution renal function impairment |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To develop and evaluate a whole-body physiologically based pharmacokinetic (WB-PBPK) model of bisoprolol and to simulate its exposure and disposition in healthy adults and patients with renal function impairment. |
| 资助项目 | [Program for Shanghai Innovative Research Team in University] ; [E-institutes of the Shanghai Municipal Education Commission] ; [National Science and Technology Supporting Projects of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294852]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.上海大学 2.中国科学院南京地理与湖泊研究所 3.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Li Guofu,Wang Kun,Chen Rui,et al. Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling[J]. ACTA PHARMACOLOGICA SINICA,2012,33(11):1359. |
| APA | Li Guofu,Wang Kun,Chen Rui,Zhao Haoru,Yang Jin,&Zheng Qingshan.(2012).Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling.ACTA PHARMACOLOGICA SINICA,33(11),1359. |
| MLA | Li Guofu,et al."Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling".ACTA PHARMACOLOGICA SINICA 33.11(2012):1359. |
入库方式： OAI收割
来源：上海药物研究所
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