Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1
文献类型：期刊论文
| 作者 | Linghua MENG ; Jian DING
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:9页码:1460 |
| 关键词 | salvicine topoisomerase II ROS DNA damage multidrug-resisitant antimetastasis |
| ISSN号 | 1671-4083 |
| 英文摘要 | Salvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated from a Chinese herb with potent growth inhibitory activity against a wide spectrum of human tumor cells in vitro and in mice bearing human tumor xenografts. Salvicine has also been found to have a profound cytotoxic effect on multidrug-resisitant (MDR) cells. Moreover, Salvicine significantly reduced the lung metastatic foci of MDA-MB-435 orthotopic xenograft. Recent studies demonstrated that salvicine is a novel non-intercalative topoisomerase II (Topo II) poison by binding to the ATPase domain, promoting DNA-Topo II binding and inhibiting Topo II-mediated DNA relegation and ATP hydrolysis. Further studies have indicated that salcivine-elicited ROS plays a central role in salvicine-induced cellular response including Topo II inhibition, DNA damage, circumventing MDR and tumor cell adhesion inhibition. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294918]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Linghua MENG,Jian DING. Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1[J]. Acta Pharmacologica Sinica,2007,28(9):1460. |
| APA | Linghua MENG,&Jian DING.(2007).Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1.Acta Pharmacologica Sinica,28(9),1460. |
| MLA | Linghua MENG,et al."Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation1".Acta Pharmacologica Sinica 28.9(2007):1460. |
入库方式： OAI收割
来源：上海药物研究所
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