Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice
文献类型：期刊论文
| 作者 | Shen Xu3 ; Jiang Hualiang3; Li Dandan3; Chen Junhua3; Chen Qing3; Li Guowei3; Chen Jing3; Yue Jianmin3; Chen Minlin2; Wang Xiaoping1
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| 刊名 | 中国药理学报：英文版
 |
| 出版日期 | 2005 |
| 卷号 | 26.0期号:002页码:220 |
| 关键词 | 磺酸 药物活动性 糖尿病 db／db 老鼠 PPARγ |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To search the peroxisome proliferator-activated receptor T (PPARγ) agonists from Swietenia mahagony extract (SINE) and observe the possible ameliorative effects of SinE on diabetic db/db mice. Methods: The PPARγ agonistic activity of SmE was screened by yeast-two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDSTS.SW software. Results: By using the clinical drug rosiglitazone as a positive control, it was found that the PPARγ agonistic activity of SInE at a concentration of 50 ug/L was approximately half that of 35.7 ug/L (0.1 umol/L) of rosiglitazone. At the dose of 1000 mg/kg, SmE remarkably decreased the blood glucose concentration of db/db mice from (15.26±2.98)to (7.58±2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group (P<0.01). Conclusion: SInE shows agonistic activity to PPART and can ameliorate the blood glucose levels of diabetic db/db mice. SmE may be thus used as a potential agent for diabetes therapy. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294926]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.同济大学 2.Animal Experiment Center, Zhejiang College of Traditional Chinese Medicine 3.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Shen Xu,Jiang Hualiang,Li Dandan,等. Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice[J]. 中国药理学报：英文版,2005,26.0(002):220. |
| APA | Shen Xu.,Jiang Hualiang.,Li Dandan.,Chen Junhua.,Chen Qing.,...&Shen Jianhua.(2005).Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice.中国药理学报：英文版,26.0(002),220. |
| MLA | Shen Xu,et al."Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice".中国药理学报：英文版 26.0.002(2005):220. |
入库方式： OAI收割
来源：上海药物研究所
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