Antidiabetic effect of a novel non-thiazolidinedione PPAR γ/α agonist on ob/ob mice
文献类型：期刊论文
| 作者 | Xi Hu; Ying Feng; Yu Shen; Xiaofeng Zhao; Juanhong Yu; Yushe Yang ; Ying Leng
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:10页码:1346 |
| 关键词 | diabetes insulin-sensitizing peroxisome proliferator-activated receptors thiazoli-dinediones |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To study whether T33, a new synthesized non-thiazolidinedione (TZD) peroxisome proliferator-activated receptor (PPAR) g/a dual agonist has an antidiabetic effect on ob/ob mice. Methods: Ob/ob mice were treated with 4 mg/kg or 8 mg/kg T33 by gavage for 20 d. Blood glucose levels were measured regularly. An oral glucose tolerance test (OGTT) and an insulin tolerance test (ITT) were preformed on d 8 and d 12, respectively. The levels of insulin, triglyceride and free fatty acid (FFA) in the serum were measured at the end of administration. The intramuscular and liver triglyceride content was also determined. Results: T33 reduced the hyperglycemia, hyperinsulinemia and hyperlipidemia of the ob/ob mice. The OGTT and ITT showed that the insulin resistance state of the ob/ob mice was obviously ameliorated after T33 treatment. After 20 d treatment with 8 mg/kg T33, the triglyceride content in the gastrocnemius muscle decreased significantly. T33 did not have any effect on triglyceride content in the liver, whereas rosiglitazone significantly increased the hepatocyte lipid deposition.Conclusion: The PPARγ/α dual agonist T33 has antidiabetic and insulin-sensitizing effects in ob/ob mice. It has the potential to be a new therapeutic candidate for the treatment of type 2 diabetes. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/294932]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Xi Hu,Ying Feng,Yu Shen,et al. Antidiabetic effect of a novel non-thiazolidinedione PPAR γ/α agonist on ob/ob mice[J]. Acta Pharmacologica Sinica,2006,27(10):1346. |
| APA | Xi Hu.,Ying Feng.,Yu Shen.,Xiaofeng Zhao.,Juanhong Yu.,...&Ying Leng.(2006).Antidiabetic effect of a novel non-thiazolidinedione PPAR γ/α agonist on ob/ob mice.Acta Pharmacologica Sinica,27(10),1346. |
| MLA | Xi Hu,et al."Antidiabetic effect of a novel non-thiazolidinedione PPAR γ/α agonist on ob/ob mice".Acta Pharmacologica Sinica 27.10(2006):1346. |
入库方式： OAI收割
来源：上海药物研究所
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