The Guadalupian Epoch was characterized by major changes in paleogeography, paleoclimate, and biodiversity. Yet, the paucity of precise and accurate radioisotopic dates from the Guadalupian stages in their type area, Guadalupe Mountains National Park in West Texas has rendered their calibration inadequate. In this study, we report high-precision U-Pb zircon geochronology by the CA-ID-TIMS method from three ash beds (2 sigma internal errors only) in the Rader Member of the Bell Canyon Formation at the Back Ridge Section (262.127 +/- 0.097 Ma, MSWD = 0.89, n = 3), the lower Pinery Member of the Bell Canyon Formation at the Frijole Section (264.23 +/- 0.13 Ma, MSWD = 0.89, n = 8) and the basal South Wells Member of the Cherry Canyon Formation at the Monolith Canyon Section (266.525 +/- 0.078 Ma, MSWD = 0.62, n = 5). The Bayesian interpolation statistics method is used to establish an age-stratigraphy model that estimates the base of the Capitanian to be 264.28 +/- 0.16 Ma, serving as the best age estimate for the Capitanian Stage at present. In addition, we review the existing geochronology from the Guadalupian Series in West Texas and seek to propose more precise temporal estimates of Guadalupian geological and biological events. These data constrain the high-frequency sequences of the Cherry Canyon and Bell Canyon formations in the Guadalupe Mountains National Park area. Accordingly, the base of the Wordian is estimated at 266.9 +/- 0.4 Ma and the Illawarra geomagnetic polarity reversal in West Texas at 267.4 +/- 0.4 Ma to 266.5 +/- 0.3 Ma. The global end-Guadalupian extinction began in the conodont zone of Jinogondolella altudaensis above the base of the Reef Trail Member of the Bell Canyon Formation and might continue to the Clarkin postbitteri postbitteri Zone in the earliest Wuchiapingian. The conodonts display a rapid evolutionary rate during this interval. This constrains the biotic crisis from ca. 260 Ma to 259 Ma based on our conodont age estimation. The emplacement of the Emeishan Large Igneous Province (ELIP) in South China has been constrained to ca. 260 Ma to 257.4 Ma based on zircon U-Pb geochronology by the CA-ID-TIMS method, overlapping with the end-Guadalupian extinction, which provides support for the temporal relationship between them. Additionally, the ELIP persisted into the early Wuchiapingian and may have hampered ecosystem restoration during the post-extinction interval.