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Two new C-19-diterpenoid alkaloids from Aconitum smirnovii

文献类型：期刊论文

作者Zhao, B (Zhao, Bo)[ 1,2 ]; Ablajan, N (Ablajan, Nurfida)[ 1,2,4 ]; Zhao, JY (Zhao, Jiang-Yu)[ 1,2 ]; Kodirova, DR (Kodirova, D. R.)[ 3 ]; Sagdullaev, SS (Sagdullaev, Sh. Sh.)[ 3 ]; Aisa, HA (Aisa, H. A.)[ 1,2 ]
刊名PHYTOCHEMISTRY LETTERS
出版日期2020
卷号38期号:8页码:96-100
关键词Aconitum smirnovii Steinb Diterpenoid alkaloids Smirnotines Antiarrhythmic Cytotoxicity Antimicrobial
ISSN号1874-3900
DOI10.1016/j.phytol.2020.05.007
英文摘要

Two new C-19-diterpenoid alkaloids, smirnotine A (1) and smirnotine B (2), together with five known diterpenoid alkaloids (3-7) were isolated from the aerial part of Aconitum smirnovii Steinb. The structures of new compounds were established on the basis of spectroscopic analyses, including HR-ESI-MS, 1D and 2D NMR spectroscopic data, while the absolute configuration of 1 was determined by quantum ECD calculation. The antiarrhythmic, cytotoxic and antimicrobial activities of these diterpenoid alkaloids were also evaluated. Compound 1 showed preventive effect of arrhythmia on arrhythmia model of anesthetized mice induced by aconitine.

WOS记录号WOS:000551768800017
源URL[http://ir.xjipc.cas.cn/handle/365002/7390]  
专题新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
新疆理化技术研究所_资源化学研究室
通讯作者Aisa, HA (Aisa, H. A.)[ 1,2 ]
作者单位1.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
2.Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, B ,Ablajan, N ,Zhao, JY ,et al. Two new C-19-diterpenoid alkaloids from Aconitum smirnovii[J]. PHYTOCHEMISTRY LETTERS,2020,38(8):96-100.
APA Zhao, B ,Ablajan, N ,Zhao, JY ,Kodirova, DR ,Sagdullaev, SS ,&Aisa, HA .(2020).Two new C-19-diterpenoid alkaloids from Aconitum smirnovii.PHYTOCHEMISTRY LETTERS,38(8),96-100.
MLA Zhao, B ,et al."Two new C-19-diterpenoid alkaloids from Aconitum smirnovii".PHYTOCHEMISTRY LETTERS 38.8(2020):96-100.

入库方式： OAI收割

来源：新疆理化技术研究所

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