Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis
文献类型：期刊论文
| 作者 | Liu, YS (Liu, Yushuang)[ 1,2,3 ]; Chen, GY (Chen, Guangying)[ 4 ]; Chen, XY (Chen, Xiaoyu)[ 1,2,3 ]; Chen, SX (Chen, Shi-Xin)[ 5 ]; Gan, LS (Gan, Li-She)[ 5 ]; Yuan, T (Yuan, Tao)[ 1,2 ] |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2020 |
| 卷号 | 81期号:9页码:2115-2119 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.8b00461 |
| 英文摘要 | Four ring-A seco-cucurbitane triterpenoids, colocynthenins A-D (1-4), together with seven known cucurbitane triterpenoids (5-11), were isolated from the fruits of Citrullus colocynthis. Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ECD calculations. Compound 1 possesses an unprecedented 2,11-lactone moiety, while compound 2 is the first reported cucurbitane triterpenoid with an unusual cyano group. Compounds 1 and 3 showed acetylcholinesterase inhibitory activities in a standard in vitro assay, with IC50 values of 2.6 and 3.1 mu M, respectively. |
| WOS记录号 | WOS:000446276600026 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/7339]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 |
| 作者单位 | 1.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 2.Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Hainan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, State Key Lab Xinjiang Indigenous Med Plants Reso, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China 5.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, YS ,Chen, GY ,Chen, XY ,et al. Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis[J]. JOURNAL OF NATURAL PRODUCTS,2020,81(9):2115-2119. |
| APA | Liu, YS ,Chen, GY ,Chen, XY ,Chen, SX ,Gan, LS ,&Yuan, T .(2020).Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis.JOURNAL OF NATURAL PRODUCTS,81(9),2115-2119. |
| MLA | Liu, YS ,et al."Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis".JOURNAL OF NATURAL PRODUCTS 81.9(2020):2115-2119. |
入库方式： OAI收割
来源：新疆理化技术研究所
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