The Toxicity and Polymorphism of beta-Amyloid Oligomers
文献类型：期刊论文
| 作者 | Huang, Ya-ru1,2; Liu, Rui-tian2 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 21期号:12页码:19 |
| 关键词 | beta-amyloid oligomers Alzheimer's disease polymorphism toxicity aggregation |
| DOI | 10.3390/ijms21124477 |
| 英文摘要 | It is widely accepted that beta-amyloid oligomers (A beta os) play a key role in the progression of Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but A beta os are highly heterogeneous in their size, structure and cytotoxicity, making the corresponding studies tough to carry out. Nevertheless, a number of studies have recently made remarkable progress in the describing the characteristics and pathogenicity of A beta os. We here review the mechanisms by which A beta os exert their neuropathogenesis for AD progression, including receptor binding, cell membrane destruction, mitochondrial damage, Ca(2+)homeostasis dysregulation and tau pathological induction. We also summarize the characteristics and pathogenicity such as the size, morphology and cytotoxicity of dimers, trimers, A beta*56 and spherical oligomers, and suggest that A beta os may play a different role at different phases of AD pathogenesis, resulting in differential consequences on neuronal synaptotoxicity and survival. It is warranted to investigate the temporal sequence of A beta os in AD human brain and examine the relationship between different A beta os and cognitive impairment. |
| WOS关键词 | CELLULAR PRION PROTEIN ; A-BETA ; ALZHEIMERS-DISEASE ; SYNAPTIC PLASTICITY ; MOUSE MODEL ; COGNITIVE IMPAIRMENT ; TAU PHOSPHORYLATION ; ADRENERGIC-RECEPTOR ; PRECURSOR PROTEIN ; MEMORY DEFICITS |
| 资助项目 | National Natural Science Foundation of China[81971610] ; National Natural Science Foundation of China[81971073] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000550123500001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/41439]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Liu, Rui-tian |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Ya-ru,Liu, Rui-tian. The Toxicity and Polymorphism of beta-Amyloid Oligomers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(12):19. |
| APA | Huang, Ya-ru,&Liu, Rui-tian.(2020).The Toxicity and Polymorphism of beta-Amyloid Oligomers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(12),19. |
| MLA | Huang, Ya-ru,et al."The Toxicity and Polymorphism of beta-Amyloid Oligomers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.12(2020):19. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。