Recent research and development of local anesthetic-loaded microspheres
文献类型：期刊论文
| 作者 | Wei, Yi3; Wu, Youbin2; Wen, Kang1,3; Bazybek, Nardana1,3; Ma, Guanghui1,3 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2020-08-14 |
| 卷号 | 8期号:30页码:6322-6332 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d0tb01129k |
| 英文摘要 | Local anesthetic drugs are widely used in postoperative analgesia, local nerve block in surgery, and in the therapy of chronic pain. Due to their short half-time, a single administration of local anesthetics merely maintains the nerve block for several hours, which cannot meet the long-term analgesia effect needed in clinical treatment. In order to break through this limitation of local anesthetics, research work regarding controlled drug release from microspheres has attracted broad and current interest. This review introduces the recent research and development in local anesthetic-loaded microspheres for future clinical applications, where for an efficient microsphere formulation, the most critical aspects are an optimum preparation method, a high loading efficiency, and an ideal release rate. This review first summarizes the recent preparation methods of local anesthetic-loaded microspheres, which includes emulsion-solvent evaporation, spray-drying, microfluidic droplets, and premix membrane emulsification technology. Next, strategies for increasing the loading efficiency of the drug in microspheres are reviewed based on the solidification conditions, polymer properties, microsphere formulation, including the external water phase, pH, and polymer concentration. Finally, the effects of the preparation conditions, material characteristics, particle characteristics, and hydrogel/microsphere composite systems on the controlled release behavior are summarized. |
| WOS关键词 | NARROW SIZE DISTRIBUTION ; DRUG-DELIVERY SYSTEMS ; CONTROLLED-RELEASE ; PLGA MICROSPHERES ; IN-VITRO ; POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES ; POSTOPERATIVE PAIN ; SUSTAINED-RELEASE ; BUPIVACAINE ; MICROPARTICLES |
| 资助项目 | National Nature Science Foundation of China[21336010] ; National Key Technology Program[2017ZX09201004014] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000555679300002 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Nature Science Foundation of China ; National Key Technology Program |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/41606]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Ma, Guanghui |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Yichang Humanwell Pharmaceut Co Ltd, Yichang 443008, Peoples R China 3.Chinese Acad Sci, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Yi,Wu, Youbin,Wen, Kang,et al. Recent research and development of local anesthetic-loaded microspheres[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(30):6322-6332. |
| APA | Wei, Yi,Wu, Youbin,Wen, Kang,Bazybek, Nardana,&Ma, Guanghui.(2020).Recent research and development of local anesthetic-loaded microspheres.JOURNAL OF MATERIALS CHEMISTRY B,8(30),6322-6332. |
| MLA | Wei, Yi,et al."Recent research and development of local anesthetic-loaded microspheres".JOURNAL OF MATERIALS CHEMISTRY B 8.30(2020):6322-6332. |
入库方式： OAI收割
来源：过程工程研究所
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