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In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection

文献类型：期刊论文

作者Ding, Zhaowen3,4; Luo, Nana3,4; Yue, Hua3,4; Gao, Yongjun2; Ma, Guanghui1,3,4; Wei, Wei3,4
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2020-08-21
卷号8期号:31页码:6845-6856
ISSN号2050-750X
DOI10.1039/d0tb00499e
英文摘要Polyethylene glycol functionalization is believed to have the capacity of endowing nanomaterials with stealth characteristics, which can diminish the arrest by macrophages and adverse immunological response. However, our previous study provided evidences that polyethylene glycol-functionalized graphene oxide (GOP) stimulated a strong immunological response to macrophages despite non-internalizationin vitro, raising safety concerns and potential immunostimulation use of GOP. In light of this finding, we herein systematically study thein vivoimmunological response upon the exposure to GOPviaintraperitoneal injection. Taking cytokines production, cell types in the peritoneal fluid, biochemical index, hematology and histopathology asin vivoindicators, we demonstrate that GOP still remains the stealth-but-activating capacity on macrophages in a time and dose-dependent manner. Specifically, the immune response can be significantly elevated after a single high-dose injection, indicating that GOP can be a new candidate adjuvant for immunotherapy. For multiple low dose injections, the immune response is gentle, temporary, and tolerable, which manifests the biocompatibility of GOP in general drug delivery. The above results can thus provide guidance for safe and rational use of GOP for various biomedical applications.
WOS关键词GOLD NANOPARTICLES ; OXIDE ; FUNCTIONALIZATION ; NANOCOMPOSITES ; RECRUITMENT ; NEUTROPHIL ; TRANSITION ; DELIVERY ; SAFE ; IL-6
资助项目National Key R&D Program of China[2017YFA0207900] ; National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000558894300020
出版者ROYAL SOC CHEMISTRY
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/41638]  
专题中国科学院过程工程研究所
通讯作者Ma, Guanghui; Wei, Wei
作者单位1.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Zhaowen,Luo, Nana,Yue, Hua,et al. In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(31):6845-6856.
APA Ding, Zhaowen,Luo, Nana,Yue, Hua,Gao, Yongjun,Ma, Guanghui,&Wei, Wei.(2020).In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection.JOURNAL OF MATERIALS CHEMISTRY B,8(31),6845-6856.
MLA Ding, Zhaowen,et al."In vivoimmunological response of exposure to PEGylated graphene oxideviaintraperitoneal injection".JOURNAL OF MATERIALS CHEMISTRY B 8.31(2020):6845-6856.

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来源：过程工程研究所

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