Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy
文献类型：期刊论文
| 作者 | Liu, Yilin3; Zhao, Luyang2; Shen, Guizhi2; Chang, Rui1,2; Zhang, Yi3; Yan, Xuehai1,2 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2020-08-05 |
| 卷号 | 598页码:7 |
| 关键词 | Flavonoids Luteolin Coordination self-assembly Nanoparticles Cancer therapy |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2020.124805 |
| 英文摘要 | Utilizing small natural molecules from traditional Chinese medicines is highly promising and advantageous in curing diverse diseases. However, the clinical translation of many of these molecular drugs was hindered due to the vulnerable chemical structure and poor solubility. Herein, we reported a coordination-driven assembly strategy to synchronously enhance the stability and solubility of a typical natural molecular drug (luteolin) through the formation of nanoparticles. The resulting nanoparticles showed much enhanced solubility in physiological environment, broadened absorption spectrum to the near-infrared region, and high stability against oxidation. Intriguingly, the coordinated assembly with ferric ion introduces the supramolecular photothermal effects, enabling the nanoparticles to act as either a chemotherapeutic agent or a photothermal agent. This work represents that the coordination assembly strategy is facile and efficient for design of nanodrugs starting from naturally-derived molecular drugs and greatly enhance their therapeutic efficacy. |
| WOS关键词 | LUTEOLIN ; DELIVERY ; PRODUCTS ; CELL |
| 资助项目 | National Natural Science Foundation of China[51861145304] ; National Natural Science Foundation of China[21703252] ; National Natural Science Foundation of China[21802144] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000561642700007 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/41736]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Shen, Guizhi; Zhang, Yi; Yan, Xuehai |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China 3.Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yilin,Zhao, Luyang,Shen, Guizhi,et al. Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,598:7. |
| APA | Liu, Yilin,Zhao, Luyang,Shen, Guizhi,Chang, Rui,Zhang, Yi,&Yan, Xuehai.(2020).Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,598,7. |
| MLA | Liu, Yilin,et al."Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 598(2020):7. |
入库方式： OAI收割
来源：过程工程研究所
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