Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis
文献类型：期刊论文
| 作者 | Wei, Peng4; Ye, Zhou4; Cao, Shuya4; Bai, Shuo1; Seeberger, Peter H.2; Yin, Jian4; Hu, Jing3 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2020-08-05 |
| 卷号 | 598页码:7 |
| 关键词 | Nanomicelle Leishmaniasis Mannose receptor |
| ISSN号 | 0927-7757 |
| DOI | 10.1016/j.colsurfa.2020.124804 |
| 英文摘要 | Drugs used to treat visceral leishmaniasis (VL) have severe side effects and face increasing resistance. We have created a mannose-functionalized nanomicelle carrying two drugs amphotericin B (AmB) and doxorubicin (DOX). The nanomicelles AmB&DOX@MCC preferentially target macrophages where Leishmania parasites reside and replicate, by the interaction between mannose residues on the micelle and mannose receptors (MRs) on the macrophage membrane. The combination of AmB and DOX leads to enhanced anti-leishmanial therapeutic efficacy through a synergistic effect. The mannose-fabricated nanomicelle is a promising formulation for leishmaniasis treatment. |
| WOS关键词 | IN-VITRO ; TARGETED DELIVERY ; HYBRID HYDROGELS ; INTERVENTION ; SYSTEM |
| 资助项目 | National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; National Key R&D Program of China[2018YFA0901700] ; National First-class Discipline Program of Light Industry Technology and Engineering[LITE2018-14] ; China Scholarship Council ; Max-Planck Society |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000561642700006 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; National Key R&D Program of China ; National First-class Discipline Program of Light Industry Technology and Engineering ; China Scholarship Council ; Max-Planck Society |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/41770]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yin, Jian; Hu, Jing |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 2.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14476 Potsdam, Germany 3.Jiangnan Univ, Wuxi Sch Med, Lihu Ave 1800, Wuxi 214122, Jiangsu, Peoples R China 4.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Lihu Ave 1800, Wuxi, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Peng,Ye, Zhou,Cao, Shuya,et al. Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,598:7. |
| APA | Wei, Peng.,Ye, Zhou.,Cao, Shuya.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,598,7. |
| MLA | Wei, Peng,et al."Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 598(2020):7. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。