Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors
文献类型：期刊论文
| 作者 | Lyu, Chengliang2,3; Lu, Guihong3; Bao, Weier1,3; Li, Feng1,3; Wang, Shuang3; Zhang, Fan3; Gao, Xiaoyong3; Kamiya, Hidehiro2; Ma, Guanghui1,3; Wei, Wei1,3 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2020-10-15 |
| 卷号 | 398页码:12 |
| ISSN号 | 1385-8947 |
| 关键词 | Tumor-macrophage chimeric cell membrane Hyaluronidase Small interfering RNA delivery Hypoxia Hypoxia-inducible factor-1 |
| DOI | 10.1016/j.cej.2020.125453 |
| 英文摘要 | Hypoxia-inducible factor-1 (HIF-1) plays a critical role in tumor development and chemotherapy resistance, and suppression of HIF-1 has emerged as a captivating antitumor approach. To efficiently silence HIF-1 in deep hypoxic tumors, we herein developed a versatile small interfering RNA delivery system that could overcome multiple physiological barriers. The system is comprised of an Fe3O4 magnetic nanocluster as the core, pre-engineered chimeric membrane for the cloak, and decorated hyaluronidase on the surface, which succeeded in prolonged circulation time, magnetic resonance imaging guidance, magnetic tumor accumulation, hypoxic site penetration, homotypic tumor targeting, and cytoplasmic trafficking. Such versatile and programmed delivery performance enabled the engineered magnetosomes to achieve the remarkable silencing of HIF-1, potent therapeutic effect and chemoresistance amelioration with few abnormalities, showing a promising modality for anticancer therapy. |
| WOS关键词 | CELL ; THERAPY |
| 资助项目 | National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005] ; National Key R&D Program of China[2017YFA0207900] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE SA |
| WOS记录号 | WOS:000561583200009 |
| 资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/41777]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Wei |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, 2-24-16 Naka Cho, Koganei, Tokyo 1848588, Japan 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lyu, Chengliang,Lu, Guihong,Bao, Weier,et al. Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors[J]. CHEMICAL ENGINEERING JOURNAL,2020,398:12. |
| APA | Lyu, Chengliang.,Lu, Guihong.,Bao, Weier.,Li, Feng.,Wang, Shuang.,...&Wei, Wei.(2020).Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors.CHEMICAL ENGINEERING JOURNAL,398,12. |
| MLA | Lyu, Chengliang,et al."Engineering magnetosomes with chimeric membrane and hyaluronidase for efficient delivery of HIF-1 siRNA into deep hypoxic tumors".CHEMICAL ENGINEERING JOURNAL 398(2020):12. |
入库方式： OAI收割
来源：过程工程研究所
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