Cancer Cell Membrane Camouflaged Semi-Yolk@Spiky-Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy
文献类型:期刊论文
作者 | Zhou, Mengyun2; Xing, Yi2; Li, Xiaoyu1; Du, Xin2; Xu, Tailin2; Zhang, Xueji2 |
刊名 | SMALL
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出版日期 | 2020-09-02 |
页码 | 11 |
关键词 | biomimetic nanomotors cancer cell membrane coating cell adhesion chemotherapy NIR light-propulsion photothermal therapy semi-yolk spiky-shell structure |
ISSN号 | 1613-6810 |
DOI | 10.1002/smll.202003834 |
英文摘要 | Cell adhesion of nanosystems is significant for efficient cellular uptake and drug delivery in cancer therapy. Herein, a near-infrared (NIR) light-driven biomimetic nanomotor is reported to achieve the improved cell adhesion and cellular uptake for synergistic photothermal and chemotherapy of breast cancer. The nanomotor is composed of carbon@silica (C@SiO2) with semi-yolk@spiky-shell structure, loaded with the anticancer drug doxorubicin (DOX) and camouflaged with MCF-7 breast cancer cell membrane (i.e., mC@SiO2@DOX). Such biomimetic mC@SiO2@DOX nanomotors display efficient self-thermophoretic propulsion due to a thermal gradient generated by asymmetrically spatial distribution. Moreover, the MCF-7 cancer cell membrane coating can remarkably reduce the bioadhesion of nanomotors in biological medium and exhibit highly specific self-recognition of the source cell line. The combination of effective propulsion and homologous targeting dramatically improves cell adhesion and the resultant cellular uptake efficiency in vitro from 26.2% to 67.5%. Therefore, the biomimetic mC@SiO2@DOX displays excellent synergistic photothermal and chemotherapy with over 91% MCF-7 cell growth inhibition rate. Such smart design of the fuel-free, NIR light-powered biomimetic nanomotor may pave the way for the application of self-propelled nanomotors in biomedicine. |
WOS关键词 | NEAR-INFRARED LIGHT ; NANOPARTICLES ; MICROMOTOR |
资助项目 | Fundamental Research Funds for the Central Universities[FRF-TP-19-017B1] ; National Natural Science Foundation of China[21501009] ; National Natural Science Foundation of China[51671181] ; National Natural Science Foundation of China[21804007] ; Beijing Municipal Science and Technology Commission[z131102002813058] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
WOS记录号 | WOS:000565028200001 |
出版者 | WILEY-V C H VERLAG GMBH |
资助机构 | Fundamental Research Funds for the Central Universities ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission |
源URL | [http://ir.ipe.ac.cn/handle/122111/41780] ![]() |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Du, Xin; Xu, Tailin; Zhang, Xueji |
作者单位 | 1.Chinese Acad Sci, Natl Engn Lab Hydrometallurg Cleaner Prod Technol, Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing Key Lab Bioengn & Sensing Technol, Dept Chem & Biol Engn, Beijing 100083, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Mengyun,Xing, Yi,Li, Xiaoyu,et al. Cancer Cell Membrane Camouflaged Semi-Yolk@Spiky-Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy[J]. SMALL,2020:11. |
APA | Zhou, Mengyun,Xing, Yi,Li, Xiaoyu,Du, Xin,Xu, Tailin,&Zhang, Xueji.(2020).Cancer Cell Membrane Camouflaged Semi-Yolk@Spiky-Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy.SMALL,11. |
MLA | Zhou, Mengyun,et al."Cancer Cell Membrane Camouflaged Semi-Yolk@Spiky-Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy".SMALL (2020):11. |
入库方式: OAI收割
来源:过程工程研究所
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