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Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly

文献类型：期刊论文

作者Li, Shukun1,3; Zhang, Wenjia2; Xue, Huadan2; Xing, Ruirui3; Yan, Xuehai1,3
刊名CHEMICAL SCIENCE
出版日期2020-09-07
卷号11期号:33页码:8644-8656
ISSN号2041-6520
DOI10.1039/d0sc02937h
英文摘要The aberrant metabolism of tumor cells creates an inimitable microenvironment featuring acidic pH, high glutathione (GSH) levels, and overexpression of certain enzymes, which benefits the overwhelming progress of a tumor. Peptide self-assembly, emerging as a biofriendly and versatile fabrication strategy, harnesses multiple noncovalent interactions to obtain a variety of nanostructures tailored on demand. Orchestrating the reversible nature of noncovalent interactions and abnormal physiological parameters in the tumor microenvironment enables peptide-based nanodrugs to be targetable or switchable, thereby improving the drugs' bioavailability and optimizing the treatment outcome. This review will focus on peptide-modulated self-assembly of photosensitizers, chemotherapeutic drugs, immunoactive agents for tumor microenvironment-oriented adaptive phototherapy, chemotherapy, immunotherapy and combinatorial therapy. We will emphasize the building block design, the intermolecular interaction principle, adaptive structural transformation in the tumor microenvironment and corresponding therapeutic efficacy, and aim to elucidate the critical role of peptide-modulated, tumor microenvironment-oriented adaptive assemblies in improving the therapeutic index. Challenges and opportunities will be covered as well to advance the development and clinical application of tumor therapies based on peptide self-assembly materials and techniques.
WOS关键词PHOTODYNAMIC THERAPY ; SUPRAMOLECULAR HYDROGELS ; EMERGING APPLICATIONS ; BETA-SHEET ; PH ; DELIVERY ; NANOPARTICLES ; CONJUGATE ; VACCINE ; NANOMATERIALS
资助项目National Natural Science Foundation of China[21802144] ; National Natural Science Fund BRICS STI Framework Program[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000562597500001
资助机构National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Program ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
源URL[http://ir.ipe.ac.cn/handle/122111/41841]  
专题中国科学院过程工程研究所
通讯作者Xue, Huadan; Xing, Ruirui; Yan, Xuehai
作者单位1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
2.Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shukun,Zhang, Wenjia,Xue, Huadan,et al. Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly[J]. CHEMICAL SCIENCE,2020,11(33):8644-8656.
APA Li, Shukun,Zhang, Wenjia,Xue, Huadan,Xing, Ruirui,&Yan, Xuehai.(2020).Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly.CHEMICAL SCIENCE,11(33),8644-8656.
MLA Li, Shukun,et al."Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly".CHEMICAL SCIENCE 11.33(2020):8644-8656.

入库方式： OAI收割

来源：过程工程研究所

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