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Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination

文献类型：期刊论文

作者Pan, Chao5; Wu, Jun5; Qing, Shuang3,4; Zhang, Xiao4; Zhang, Lulu5; Yue, Hua4; Zeng, Ming2; Wang, Bin2; Yuan, Zheng1; Qiu, Yefeng1
刊名ADVANCED MATERIALS
出版日期2020-09-02
页码13
关键词AB(5)toxins biosynthesis conjugate vaccines nanovaccines self-assembled proteins
ISSN号0935-9648
DOI10.1002/adma.202002940
英文摘要Recent years have seen enormous advances in nanovaccines for both prophylactic and therapeutic applications, but most of these technologies employ chemical or hybrid semi-biosynthetic production methods. Thus, production of nanovaccines has to date failed to exploit biology-only processes like complex sequential post-translational biochemical modifications and scalability, limiting the realization of the initial promise for offering major performance advantages and improved therapeutic outcomes over conventional vaccines. A Nano-B5 platform for in vivo production of fully protein-based, self-assembling, stable nanovaccines bearing diverse antigens including peptides and polysaccharides is presented here. Combined with the self-assembly capacities of pentamer domains from the bacterial AB(5)toxin and unnatural trimer peptides, diverse nanovaccine structures can be produced in commonEscherichia colistrains and in attenuated pathogenic strains. Notably, the chassis of these nanovaccines functions as an immunostimulant. After showing excellent lymph node targeting and immunoresponse elicitation and safety performance in both mouse and monkey models, the strong prophylactic effects of these nanovaccines against infection, as well as their efficient therapeutic effects against tumors are further demonstrated. Thus, the Nano-B5 platform can efficiently combine diverse modular components and antigen cargos to efficiently generate a potentially very large diversity of nanovaccine structures using many bacterial species.
WOS关键词VIRUS-LIKE PARTICLES ; CHOLERA-TOXIN ; O-ANTIGEN ; DELIVERY ; VACCINES ; NANOTECHNOLOGY ; ACTIVATION ; RECEPTOR ; DESIGN ; CELLS
资助项目National Natural Science Foundation of China[81930122] ; National Natural Science Foundation of China[81871314] ; National Natural Science Foundation of China[31700802] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[81773619] ; National Natural Science Foundation of China[21821005] ; National Science and Technology Major Project[2018ZX10101003-005] ; National Science and Technology Major Project[2018ZX09711003-013] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000565425700001
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Science and Technology Major Project ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/41875]  
专题中国科学院过程工程研究所
通讯作者Zhu, Li; Wei, Wei; Ma, Guanghui; Wang, Hengliang
作者单位1.Acad Mil Med Sci, Anim Ctr, 20 Dongda St, Beijing 100071, Peoples R China
2.Natl Inst Food & Drug Control, 31 Huatuo Rd, Beijing 102629, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China
5.Beijing Inst Biotechnol, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China
推荐引用方式
GB/T 7714		 Pan, Chao,Wu, Jun,Qing, Shuang,et al. Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination[J]. ADVANCED MATERIALS,2020:13.
APA Pan, Chao.,Wu, Jun.,Qing, Shuang.,Zhang, Xiao.,Zhang, Lulu.,...&Wang, Hengliang.(2020).Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination.ADVANCED MATERIALS,13.
MLA Pan, Chao,et al."Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination".ADVANCED MATERIALS (2020):13.

入库方式： OAI收割

来源：过程工程研究所

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