中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 过程工程研究所
  3. 中国科学院过程工程研究所
Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy

文献类型：期刊论文

作者Wang, Jianghua1,2; Wang, Shuang2; Ye, Tong1,2; Li, Feng1,2; Gao, Xiaoyong2; Wang, Yan1,2; Ye, Peng2; Qing, Shuang1,2; Wang, Changlong1,2; Yue, Hua2
刊名ADVANCED SCIENCE
出版日期2020-08-15
页码17
关键词delivery modes hydrogels lymph nodes nanovaccines tumor immunotherapy
DOI10.1002/advs.202001108
英文摘要Nanovaccines have attracted booming interests in vaccinology studies, but the profound impacts of their delivery mode on immune response remain unrealized. Herein, immunostimulatory CpG-modified tumor-derived nanovesicles (CNVs) are used as a nanovaccine testbed to initially evaluate the impacts of three distinct delivery modes, including mono-pulse CNVs, staggered-pulse CNVs, and gel-confined CNVs. Fundamentally, delivery mode has enormous impacts on the immunomodulatory effects, altering the spatiotemporal distribution of nanovaccine residence and dendritic cell-T cell interaction in lymph nodes, and finally affecting subsequent T cell-mediated immune performance. As a result, the gel-confined delivery mode offers the best therapeutic performance in multiple tumor models. When extending evaluation to examine how the various delivery modes impact the performance of liposome-based nanovaccines, similar trends in intralymph node distribution and antitumor effect are observed. This work provides a strong empirical foundation that nanovaccine researchers should position delivery mode near the top of their considerations for the experimental design, which should speed up nanovaccine development and facilitate efficient selection of appropriate delivery modes in the clinic.
WOS关键词CELLS IN-VIVO ; DENDRITIC CELLS ; LYMPH-NODE ; QUATERNIZED CHITOSAN ; VACCINE DELIVERY ; HYDROGEL ; NANOPARTICLES ; ENCAPSULATION ; BIOMATERIALS ; ANTIGENS
资助项目Innovative Research Group Project of the National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Key Research and Development Program of China[2017YFA0207900] ; Beijing Municipal Natural Science Foundation[2202056]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000565309100001
出版者WILEY
资助机构Innovative Research Group Project of the National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key Research and Development Program of China ; Beijing Municipal Natural Science Foundation
源URL[http://ir.ipe.ac.cn/handle/122111/41902]  
专题中国科学院过程工程研究所
通讯作者Wei, Wei; Ma, Guanghui
作者单位1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jianghua,Wang, Shuang,Ye, Tong,et al. Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy[J]. ADVANCED SCIENCE,2020:17.
APA Wang, Jianghua.,Wang, Shuang.,Ye, Tong.,Li, Feng.,Gao, Xiaoyong.,...&Ma, Guanghui.(2020).Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy.ADVANCED SCIENCE,17.
MLA Wang, Jianghua,et al."Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy".ADVANCED SCIENCE (2020):17.

入库方式： OAI收割

来源：过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。