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Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection

文献类型：期刊论文

作者Wu, Yanyue1,2; Lu, Zhiguo1,2; Li, Yan2; Yang, Jun1,2; Zhang, Xin1,2
刊名NANOMATERIALS
出版日期2020-08-01
卷号10期号:8页码:21
关键词theranostics iron oxide magnetic nanoparticles blood-brain barrier surface coating target therapy
DOI10.3390/nano10081441
英文摘要Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer's disease (AD) and Parkinson's disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.
WOS关键词ALZHEIMERS-DISEASE ; DRUG-DELIVERY ; IMAGING PROBE ; CANCER ; ACID ; MRI ; DESIGN ; PERMEABILITY ; STRATEGIES ; CHITOSAN
资助项目National High-tech Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283] ; Natural Science Foundation of Beijing Municipality[L172046] ; Natural Science Foundation of Beijing Municipality[2192057]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000567363900001
出版者MDPI
资助机构National High-tech Research and Development Program ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
源URL[http://ir.ipe.ac.cn/handle/122111/41945]  
专题中国科学院过程工程研究所
通讯作者Yang, Jun; Zhang, Xin
作者单位1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yanyue,Lu, Zhiguo,Li, Yan,et al. Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection[J]. NANOMATERIALS,2020,10(8):21.
APA Wu, Yanyue,Lu, Zhiguo,Li, Yan,Yang, Jun,&Zhang, Xin.(2020).Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection.NANOMATERIALS,10(8),21.
MLA Wu, Yanyue,et al."Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection".NANOMATERIALS 10.8(2020):21.

入库方式： OAI收割

来源：过程工程研究所

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