Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR
文献类型：期刊论文
| 作者 | Xie, Junshuai1,2; Li, Haidong1,2; Zhang, Huiting1; Zhao, Xiuchao1,2; Shi, Lei1,2; Zhang, Ming1; Xiao, Sa1,2; Deng, He1,2; Wang, Ke3; Yang, Hao3 |
| 刊名 | NMR IN BIOMEDICINE
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 32期号:5页码:11 |
| 关键词 | compressed sensing COPD gas exchange hyperpolarized Xe-129 lung pulmonary microstructure |
| ISSN号 | 0952-3480 |
| DOI | 10.1002/nbm.4068 |
| 英文摘要 | Pulmonary diseases usually result in changes of the blood-gas exchange function in the early stages. Gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized Xe-129 MR via chemical shift saturation recovery (CSSR) and diffusion-weighted imaging (DWI), respectively. Generally, CSSR and DWI data have been collected in separate breaths in humans. Unfortunately, the lung inflation level cannot be the exactly same in different breaths, which causes fluctuations in blood-gas exchange and pulmonary microstructure. Here we combine CSSR and DWI obtained with compressed sensing, to evaluate the gas diffusion and exchange function within a single breath-hold in humans. A new parameter, namely the perfusion factor of the respiratory membrane (SVRd/g), is proposed to evaluate the gas exchange function. Hyperpolarized Xe-129 MR data are compared with pulmonary function tests and computed tomography examinations in healthy young, age-matched control, and chronic obstructive pulmonary disease human cohorts. SVRd/g decreases as the ventilation impairment and emphysema index increase. Our results indicate that the proposed method has the potential to detect the extent of lung parenchyma destruction caused by age and pulmonary diseases, and it would be useful in the early diagnosis of pulmonary diseases in clinical practice. |
| 资助项目 | Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SLH018] ; National Key R&D Program of China[2016YFC1304700] ; National Key R&D Program of China[2017YFA0505400] ; National Natural Science Foundation of China[81227902] ; National Natural Science Foundation of China[81601491] ; National Natural Science Foundation of China[81625011] ; Hubei Provincial Natural Science Foundation of China[2017CFA013] ; Hubei Provincial Natural Science Foundation of China[2018ACA143] ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) |
| WOS研究方向 | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000465199500010 |
| 出版者 | WILEY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/7643]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Zhou, Xin |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Junshuai,Li, Haidong,Zhang, Huiting,et al. Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR[J]. NMR IN BIOMEDICINE,2019,32(5):11. |
| APA | Xie, Junshuai.,Li, Haidong.,Zhang, Huiting.,Zhao, Xiuchao.,Shi, Lei.,...&Zhou, Xin.(2019).Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR.NMR IN BIOMEDICINE,32(5),11. |
| MLA | Xie, Junshuai,et al."Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized Xe-129 MR".NMR IN BIOMEDICINE 32.5(2019):11. |
入库方式： OAI收割
来源：武汉植物园
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