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Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella

文献类型：期刊论文

作者Lu, Xiao-Bing1,3; Wang, Zhao-Xi1,3; Liu, Shu-Bo1,3; Zhang, Xiang-Yang1,3; Lu, Long-Feng3; Li, Shun3; Chen, Dan-Dan3; Nie, Pin3; Zhang, Yong-An2,3,4
刊名FRONTIERS IN IMMUNOLOGY
出版日期2019-05-22
卷号10页码:12
关键词CIITA MHC II IRF1 IRF2 IFN-gamma grass carp
ISSN号1664-3224
DOI10.3389/fimmu.2019.01106
英文摘要Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-gamma-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-gamma or IFN-gamma rel, only IFN-gamma could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression.
资助项目National Natural Science Foundation of China[31725026] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000468760700001
出版者FRONTIERS MEDIA SA
源URL[http://202.127.146.157/handle/2RYDP1HH/7877]  
专题中国科学院武汉植物园
通讯作者Zhang, Yong-An
作者单位1.Univ Chinese Acad Sci, Coll Modern Agr Sci, Beijing, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
4.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Xiao-Bing,Wang, Zhao-Xi,Liu, Shu-Bo,et al. Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella[J]. FRONTIERS IN IMMUNOLOGY,2019,10:12.
APA Lu, Xiao-Bing.,Wang, Zhao-Xi.,Liu, Shu-Bo.,Zhang, Xiang-Yang.,Lu, Long-Feng.,...&Zhang, Yong-An.(2019).Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella.FRONTIERS IN IMMUNOLOGY,10,12.
MLA Lu, Xiao-Bing,et al."Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella".FRONTIERS IN IMMUNOLOGY 10(2019):12.

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来源：武汉植物园

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