Comparative and chemometric analysis of correlations between the chemical fingerprints and anti-proliferative activities of ganoderic acids from three Ganoderma species
文献类型：期刊论文
| 作者 | Zhang, Chunyun1,3; Fu, Dan1,2; Chen, Guilin1,3; Guo, Mingquan1,3 |
| 刊名 | PHYTOCHEMICAL ANALYSIS
 |
| 出版日期 | 2019-07-01 |
| 卷号 | 30期号:4页码:474-480 |
| 关键词 | anti-proliferative chemometrics fingerprints ganoderic acids Ganoderma lucidum |
| ISSN号 | 0958-0344 |
| DOI | 10.1002/pca.2830 |
| 英文摘要 | Introduction Investigation on ganoderic acids (GAs) from different cultivars and origins of Ganoderma species, regarding to their composition, contents and bioactivities, will be of great importance for the development and quality control of Ganoderma-based healthcare products or drugs. Objective Comparative and chemometric analysis of different Ganoderma species were conducted to reveal the correlations between their chemical fingerprints and anti-proliferative activities. Methodology Six Ganoderma samples with different origins and parts of fruiting body (pileus and stipe) were extracted with chloroform and enriched by a SPE-C18 cartridge. The eluents were used for high-performance liquid chromatography ultraviolet electrospray ionisation tandem mass spectrometry (HPLC-UV/ESI-MS/MS) analysis and cytotoxicity assay with three cancer cell lines (SGC-7901, HT-29 and Hep G2). Chemometric analysis was applied to correlate their chemical compositions and corresponding bioactivities. Results Sixteen peaks (accounting for 70% of the total peak areas) were identified as GAs, and their contents ranged from 0.368 to 10.8 mu g/g in various Ganoderma species. The extracts from three Ganoderma species had significant anti-proliferative activities (inhibitory rates ranged from 70.8% to 80.7%), and extracts from Lurongzhi showed remarkable inhibition to all three cancer cells (inhibitory rates range from 81.6% to 92.1%). Finally, chemometric analysis revealed that 3,7,12-trihydroxy-4,4,14-trimethyl-11,15-dioxochol-8-en-24-oic acid and 12-acetoxy-15-hydroxy-4,4,14-trimethyl-3,7,11-trioxochol-8-en-24-oic acid were the two compounds with most potential anti-proliferative activity for SGC-7901. Conclusion The correlations between chemical fingerprints and anti-proliferative activities of various Ganoderma species give remarkable insight into the true bioactive components of chemical markers for the quality assessment of the Ganoderma resources, and provide a good guidance for the study on the chemical spectrum-bioactivity relationship. |
| 资助项目 | One Hundred Talents Project from Chinese Academy of Sciences[29Y429291a0129] ; Major Project for Special Technology Innovation of Hubei Province-Sino-foreign Cooperation Project[2017AHB054] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000469994300011 |
| 出版者 | WILEY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/7926]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Guo, Mingquan |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chunyun,Fu, Dan,Chen, Guilin,et al. Comparative and chemometric analysis of correlations between the chemical fingerprints and anti-proliferative activities of ganoderic acids from three Ganoderma species[J]. PHYTOCHEMICAL ANALYSIS,2019,30(4):474-480. |
| APA | Zhang, Chunyun,Fu, Dan,Chen, Guilin,&Guo, Mingquan.(2019).Comparative and chemometric analysis of correlations between the chemical fingerprints and anti-proliferative activities of ganoderic acids from three Ganoderma species.PHYTOCHEMICAL ANALYSIS,30(4),474-480. |
| MLA | Zhang, Chunyun,et al."Comparative and chemometric analysis of correlations between the chemical fingerprints and anti-proliferative activities of ganoderic acids from three Ganoderma species".PHYTOCHEMICAL ANALYSIS 30.4(2019):474-480. |
入库方式： OAI收割
来源：武汉植物园
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