Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA
文献类型：期刊论文
| 作者 | Li, Wenjiao2; Li, Ning4; Dai, Shiyu1; Hou, Guoqing2; Guo, Kanglin2; Chen, Xuanzuo2; Yi, Changhua5; Liu, Weiyong3; Deng, Fei1; Wu, Yaosong4 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 33期号:9页码:9929-9944 |
| 关键词 | ZIKV immune evasion IFN-beta |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.201900260R |
| 英文摘要 | Recently, Zika virus (ZIKV) has generated extraordinary concern because of its severe neurotoxicity. Disturbingly, there is no vaccine or specific drug to prevent or treat the diseases caused by ZIKV infection. Thus, it is extremely urgent to characterize the pathogenesis of ZIKV. It has been documented that ZIKV can evade antiviral responses of host cells. Here, we demonstrate that ZIKV strain SZ-WIV01 down-regulates the production of type I IFN and IFN-stimulated genes along with the expression of mitochondrial antiviral signaling protein (MAVS) and mediator of IFN regulatory factor 3 activation (MITA). In the mechanism, ZIKV nonstructural (NS) 3 and NS2B3 negatively regulate IFN-related retinoic acid-inducible gene I-like receptor signaling pathway by targeting MAVS and MITA, respectively. Overexpression of ZIKV NS3 and NS2B3 dramatically inhibits expression of IFN-beta. ZIKV NS3 interacts with MAVS, and NS2B3 interacts with MITA, which catalyzes K48-linked polyubiquitination of MAVS and MITA for degradation. Further investigations suggest that ZIKV NS2B3 impairs polyinosinic:polycytidylic acid-triggered K63-linked polyubiquitination of MITA, thereby subverting the activation of downstream sensors. Our study reveals an undiscovered mechanism for ZIKV to escape the innate immune response, providing new insights into clinical study of vaccines or effective drugs.-Li, W., Li, N., Dai, S., Hou, G., Guo, K., Chen, X., Yi, C., Liu, W., Deng, F., Wu, Y., Cao, X. Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA. |
| 资助项目 | National Natural Science Foundation of China[31571431] ; National Natural Science Foundation of China[31771541] ; National Natural Science Foundation of China[81503490] ; Natural Science Foundation of Hubei Province of China[2016CFA053] ; Intergovernmental Special Program of State Key Research and Development Plan from the Ministry of Science and Technology of China[2016YFE0113500] ; National Mega Project on Major Infectious Diseases Prevention[2017ZX10103005-007] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000482214200019 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/7976]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Wu, Yaosong; Cao, Xuan |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Clin Lab, Wuhan, Hubei, Peoples R China 4.Henan Univ Tradit Chinese Med, Sch Basic Med, Inst Canc Mol Mech & Drug Targets, Zhengzhou, Henan, Peoples R China 5.Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Wenjiao,Li, Ning,Dai, Shiyu,et al. Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA[J]. FASEB JOURNAL,2019,33(9):9929-9944. |
| APA | Li, Wenjiao.,Li, Ning.,Dai, Shiyu.,Hou, Guoqing.,Guo, Kanglin.,...&Cao, Xuan.(2019).Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA.FASEB JOURNAL,33(9),9929-9944. |
| MLA | Li, Wenjiao,et al."Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA".FASEB JOURNAL 33.9(2019):9929-9944. |
入库方式： OAI收割
来源：武汉植物园
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