Ponatinib Protects Mice From Lethal Influenza Infection by Suppressing Cytokine Storm
文献类型：期刊论文
| 作者 | Chen, Si1,2; Liu, Ge1,2; Chen, Jungang2; Hu, Ao1,2; Zhang, Li1,2; Sun, Wenyu1,2; Tang, Wei2; Liu, Chunlan2; Zhang, Haiwei2; Ke, Chang4 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2019-06-21 |
| 卷号 | 10页码:13 |
| 关键词 | cytokine storm immunomodulator influenza A virus ponatinib pro-inflammatory cytokine |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2019.01393 |
| 英文摘要 | Excessive inflammation associated with the uncontrolled release of pro-inflammatory cytokines is the main cause of death from influenza virus infection. Previous studies have indicated that inhibition of interferon gamma-induced protein 10 (IP-10), interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), or their cognate receptors has beneficial effects. Here, by using monocytic U937 cells that capable of secreting the three important cytokines during influenza A virus infection, we measured the inhibitory activities on the production of three cytokines of six anti-inflammatory compounds reported in other models of inflammation. We found that ponatinib had a highly inhibitory effect on the production of all three cytokines. We tested ponatinib in a mouse influenza model to assess its therapeutic effects with different doses and administration times and found that the delayed administration of ponatinib was protective against lethal influenza A virus infection without reducing virus titers. Therefore, we suggest that ponatinib may serve as a new immunomodulator in the treatment of influenza. |
| 资助项目 | Important Hubei Science and Technology Innovation Plan[2015ACA062] ; Natural Science Foundation of Hubei Province[2018CFB244] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000472468000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/8028]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Wu, Jianguo; Chen, Xulin |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 3.Jinan Univ, Guangzhou Key Lab Virol, Inst Med Microbiol, Guangzhou, Guangdong, Peoples R China 4.Wuhan Virolead Biopharmaceut Co, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Si,Liu, Ge,Chen, Jungang,et al. Ponatinib Protects Mice From Lethal Influenza Infection by Suppressing Cytokine Storm[J]. FRONTIERS IN IMMUNOLOGY,2019,10:13. |
| APA | Chen, Si.,Liu, Ge.,Chen, Jungang.,Hu, Ao.,Zhang, Li.,...&Chen, Xulin.(2019).Ponatinib Protects Mice From Lethal Influenza Infection by Suppressing Cytokine Storm.FRONTIERS IN IMMUNOLOGY,10,13. |
| MLA | Chen, Si,et al."Ponatinib Protects Mice From Lethal Influenza Infection by Suppressing Cytokine Storm".FRONTIERS IN IMMUNOLOGY 10(2019):13. |
入库方式： OAI收割
来源：武汉植物园
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