Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior
文献类型：期刊论文
| 作者 | Wang, Haitao6; Chen, Jiahui6; Xu, Xiaotong6; Sun, Wen-Jian3; Chen, Xi3; Zhao, Fei4; Luo, Min-Hua4; Liu, Chunhua5; Guo, Yiping5; Xie, Wen7 |
| 刊名 | PLOS BIOLOGY
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 17期号:8页码:26 |
| ISSN号 | 1544-9173 |
| DOI | 10.1371/journal.pbio.3000417 |
| 英文摘要 | Threatening sounds can elicit a series of defensive behavioral reactions in animals for survival, but the underlying neural substrates are not fully understood. Here, we demonstrate a previously unexplored neural pathway in mice that projects directly from the auditory cortex (ACx) to the lateral periaqueductal gray (lPAG) and controls noise-evoked defensive behaviors. Electrophysiological recordings showed that the lPAG could be excited by a loud noise that induced an escape-like behavior. Trans-synaptic viral tracing showed that a great number of glutamatergic neurons, rather than GABAergic neurons, in the lPAG were directly innervated by those in layer V of the ACx. Activation of this pathway by optogenetic manipulations produced a behavior in mice that mimicked the noise-evoked escape, whereas inhibition of the pathway reduced this behavior. Therefore, our newly identified descending pathway is a novel neural substrate for noise-evoked escape and is involved in controlling the threat-related behavior. |
| 资助项目 | National Natural Science Foundation of China[91732303] ; National Natural Science Foundation of China[81870877] ; National Natural Science Foundation of China[81570915] ; National Key Research and Development Program of China[2016YFC1305900] ; Anhui Provincial Natural Science Foundation[1808085MH244] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000483408500031 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/8432]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Chen, Lin; Zhang, Zhi |
| 作者单位 | 1.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China 2.Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei, Anhui, Peoples R China 3.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China 6.Univ Sci & Technol China, Dept Biophys & Neurobiol, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China 7.Anhui Mental Hlth Ctr, Dept Psychol, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Haitao,Chen, Jiahui,Xu, Xiaotong,et al. Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior[J]. PLOS BIOLOGY,2019,17(8):26. |
| APA | Wang, Haitao.,Chen, Jiahui.,Xu, Xiaotong.,Sun, Wen-Jian.,Chen, Xi.,...&Zhang, Zhi.(2019).Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior.PLOS BIOLOGY,17(8),26. |
| MLA | Wang, Haitao,et al."Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior".PLOS BIOLOGY 17.8(2019):26. |
入库方式： OAI收割
来源：武汉植物园
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