Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition
文献类型：期刊论文
| 作者 | Lin, Fuchun2,3; Zivadinov, Robert1,2; Hagemeier, Jesper2; Weinstock-Guttman, Bianca2; Vaughn, Caila2; Gandhi, Sirin2; Jakimovski, Dejan2; Hulst, Hanneke E.4; Benedict, Ralph H. B.2; Bergsland, Niels2 |
| 刊名 | MULTIPLE SCLEROSIS JOURNAL
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 25期号:9页码:1243-1254 |
| 关键词 | Multiple sclerosis thalamus functional connectivity nuclei-specific fatigue cognition |
| ISSN号 | 1352-4585 |
| DOI | 10.1177/1352458518788218 |
| 英文摘要 | Background: The thalamus, affected early in multiple sclerosis (MS), is a heterogeneous composition of functionally distinct nuclei and is associated with fatigue, cognition, and other outcomes. However, most previous functional imaging studies considered the thalamus only as a whole. Objective: To investigate MS-related abnormalities in nuclei-specific thalamic functional connectivity (FC) and their associations with fatigue and cognitive outcomes. Methods: Resting-state functional magnetic resonance imaging (fMRI) was analyzed in 64 MS patients and 26 healthy controls (HC). Whole-brain FC maps for four thalamic subregions seeds were computed for each subject. FC maps were compared between groups, and group by FC interaction effects were assessed for fatigue and cognitive measures. Results: MS patients had decreased FC between the left medial thalamic nuclei and left angular gyrus and reduced FC between the left posterior thalamic nuclei and left supramarginal gyrus, as well as decreased right medial thalamic nuclei connectivity with bilateral caudate/thalamus and left cerebellar areas (p < 0.05 corrected). MS patients had increased FC between the left anterior thalamic nuclei and anterior cingulate cortex bilaterally. There were significant relationships between connectivity alterations and fatigue and cognitive measures between groups (p < 0.05 corrected). Conclusion: FC alteration is nuclei-specific and is differentially associated with fatigue and cognition. |
| 资助项目 | Buffalo Neuroimaging Analysis Center |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000478623000009 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/8466]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Dwyer, Michael G. |
| 作者单位 | 1.SUNY Buffalo, Jacobs Sch Med & Biomed Sci, MRI Clin & Translat Res Ctr, Buffalo, NY USA 2.SUNY Buffalo, Dept Neurol, Buffalo Neuroimaging Anal Ctr, Jacobs Sch Med & Biomed Sci, 100 High St, Buffalo, NY 14203 USA 3.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China 4.Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Amsterdam, Netherlands |
| 推荐引用方式 GB/T 7714 | Lin, Fuchun,Zivadinov, Robert,Hagemeier, Jesper,et al. Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition[J]. MULTIPLE SCLEROSIS JOURNAL,2019,25(9):1243-1254. |
| APA | Lin, Fuchun.,Zivadinov, Robert.,Hagemeier, Jesper.,Weinstock-Guttman, Bianca.,Vaughn, Caila.,...&Dwyer, Michael G..(2019).Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition.MULTIPLE SCLEROSIS JOURNAL,25(9),1243-1254. |
| MLA | Lin, Fuchun,et al."Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition".MULTIPLE SCLEROSIS JOURNAL 25.9(2019):1243-1254. |
入库方式： OAI收割
来源：武汉植物园
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