Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases
文献类型：期刊论文
| 作者 | Chen, Cao3,4; Hu, Chao3,5; Shi, Qi3; Zhou, Wei3; Mao, Kang3; Wang, Yuan3; Liu, Lian3,5; Chen, Jia3,5; Xia, Ying3,5; Dong, Xiao-Ping1,2,3,4,6 |
| 刊名 | FRONTIERS IN NEUROSCIENCE
 |
| 出版日期 | 2019-09-04 |
| 卷号 | 13页码:9 |
| 关键词 | prion genetic prion disease CSF 14-3-3 tau |
| DOI | 10.3389/fnins.2019.00934 |
| 英文摘要 | Background: The abnormal alterations of proteins 14-3-3 and tau in cerebrospinal fluid (CSF) are widely used for the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD), while the situations of CSF biomarkers in genetic prion diseases (gPrDs), particularly in Chinese gPrDs patients, have not been well documented. Methods: Here, with the help of commercial 14-3-3 and total tau ELISA kits, we evaluated the levels of proteins 14-3-3 and tau in the CSF samples of 140 Chinese patients of 14 different types of gPrDs. Results: We found that CSF 14-3-3 ELISA values in the patients with P102L GSS and D178N FFI were remarkably low, while those in the patients with T188K, E196A, and E200K gCJD were relatively high. Linear correlation assays identified a positive correlation between positive rate in Western blot (WB) and ELISA values of CSF 14-3-3. ELISA assays for total tau in CSF samples identified relatively high levels in the cases of T188K, E196A, and E200K gCJD (median: 133840.81, 159992.80, and 153342.92 AU/ml), but relatively low levels in those of P102L GSS and D178N FFI (median: 64397.77 and 43856.79 AU/ml). Conclusion: These data illustrate heterogeneous profiles of CSF 14-3-3 and tau in various types of gPrDs, depending on the differences in the mutations in PRNP. |
| 资助项目 | National Natural Science Foundation of China[81772197] ; National Natural Science Foundation of China[81401670] ; National Natural Science Foundation of China[81630062] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2018RC330004] ; National Key R&D Program of China[2018YFC1200305] ; National Key R&D Program of China[2016YFC1202700] ; SKLID Development Grant[2015SKLID503] ; SKLID Development Grant[2016SKLID603] ; SKLID Development Grant[2019SKLID401] ; Young Scholar Scientific Research Foundation of China CDC[2016A101] ; National Science and Technology Major Project of China[2018ZX10102001] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000483781700002 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/8559]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Dong, Xiao-Ping |
| 作者单位 | 1.Chinese Ctr Dis Control & Prevent, Ctr Global Publ Hlth, Beijing, Peoples R China 2.China Acad Chinese Med Sci, Beijing, Peoples R China 3.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, NHC Key Lab Med Virol & Viral Dis, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Biosafety Mega Sci, Wuhan, Hubei, Peoples R China 5.Heilongjiang Bayi Agr Univ, Coll Life Sci & Technol, Daqing, Peoples R China 6.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Cao,Hu, Chao,Shi, Qi,et al. Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases[J]. FRONTIERS IN NEUROSCIENCE,2019,13:9. |
| APA | Chen, Cao.,Hu, Chao.,Shi, Qi.,Zhou, Wei.,Mao, Kang.,...&Dong, Xiao-Ping.(2019).Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases.FRONTIERS IN NEUROSCIENCE,13,9. |
| MLA | Chen, Cao,et al."Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion Diseases".FRONTIERS IN NEUROSCIENCE 13(2019):9. |
入库方式： OAI收割
来源：武汉植物园
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