中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 武汉植物园
  3. 中国科学院武汉植物园
Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers

文献类型：期刊论文

作者Lin, Fuchun2,3; Wu, Guangyao1,4; Zhu, Ling4; Lei, Hao2,3
刊名FRONTIERS IN HUMAN NEUROSCIENCE
出版日期2019-07-31
卷号13页码:9
关键词insula cortical thickness heavy smokers region-specific changes structural MRI
ISSN号1662-5161
DOI10.3389/fnhum.2019.00265
英文摘要Insula plays an essential role in maintaining the addiction to cigarette smoking and smoking-related alterations on the insular volume and density have been reported in smokers. However, less is known about the effects of chronic cigarette smoking on the insular cortical thickness. In this study, we explored the region-specific changes of insular cortical thickness in heavy smokers and their relations with smoking-related variables. 37 heavy smokers (29 males, mean age 47.19 +/- 7.22 years) and 37 nonsmoking healthy controls (29 males, mean age 46.95 +/- 8.45 years) participated in the study. Subregional insular cortical thickness was evaluated and compared between the two groups. Correlation analysis was performed to investigate relationships between the insular cortical thickness and clinical characteristics in heavy smokers. There was no statistical difference on the cortical thickness in the left insula (p = 0.536) between the two groups while heavy smokers had a slightly thinner cortical thickness in the right insula (p = 0.048). In addition, heavy smokers showed a greater cortical thinning in the anterior (p = 0.0084) and superior (p = 0.0054) segment of the circular sulcus of the right insula as well as the inferior (p = 0.012) segment of the circular sulcus of the left insula. Moreover, the cortical thickness of the superior segment of the circular sulcus of the left insula was correlated negatively with nicotine severity (r = -0.423; p = 0.009) and the longer cigarette exposure was associated with the cortical thinning in the long insular gyrus and central sulcus of the right insula (r = -0.475; p = 0.003). Our findings indicate that chronic cigarette use is associated with region-specific insular thinning, which has the potential to improve our understanding of the specific roles of insular subregions in nicotine addiction.
资助项目National Natural Science Foundation of China[81571757] ; Frontier Scientific Significant Breakthrough Project of CAS[QYZDB-SSW-SLH046]
WOS研究方向Neurosciences & Neurology ; Psychology
语种英语
WOS记录号WOS:000478033500003
出版者FRONTIERS MEDIA SA
源URL[http://202.127.146.157/handle/2RYDP1HH/8609]  
专题中国科学院武汉植物园
通讯作者Lin, Fuchun
作者单位1.Shenzhen Univ, Med Coll, Shenzhen Univ Gen Hosp, Dept Med Imaging, Shenzhen, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan, Hubei, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Fuchun,Wu, Guangyao,Zhu, Ling,et al. Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2019,13:9.
APA Lin, Fuchun,Wu, Guangyao,Zhu, Ling,&Lei, Hao.(2019).Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers.FRONTIERS IN HUMAN NEUROSCIENCE,13,9.
MLA Lin, Fuchun,et al."Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers".FRONTIERS IN HUMAN NEUROSCIENCE 13(2019):9.

入库方式： OAI收割

来源：武汉植物园

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。