Vitamin D Regulates the Microbiota to Control the Numbers of ROR gamma t/FoxP3+Regulatory T Cells in the Colon
文献类型：期刊论文
| 作者 | Cantorna, Margherita T.1,3; Lin, Yang-Ding1,3; Arora, Juhi1,3; Bora, Stephanie1,2,3; Tian, Yuan1,3,4; Nichols, Robert G.3; Patterson, Andrew D.3 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2019-07-30 |
| 卷号 | 10页码:10 |
| 关键词 | vitamin D T regulatory (T reg) cells inflammatory bowel diseases microbiota gnotobiotic mice |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2019.01772 |
| 英文摘要 | The active form of vitamin D (1,25(OH)(2)D) suppresses experimental models of inflammatory bowel disease in part by regulating the microbiota. In this study, the role of vitamin D in the regulation of microbe induced ROR gamma t/FoxP3+ T regulatory (reg) cells in the colon was determined. Vitamin D sufficient (D+) mice had significantly higher frequencies of FoxP3+ and ROR gamma t/FoxP3+ T reg cells in the colon compared to vitamin D deficient (D-) mice. The higher frequency of ROR gamma t/FoxP3+ T reg cells in D+ colon correlated with higher numbers of bacteria from the Clostridium XIVa and Bacteroides in D+ compared to D- cecum. D- mice with fewer ROR gamma t/FoxP3+ T reg cells were significantly more susceptible to colitis than D+ mice. Transfer of the cecal bacteria from D+ or D- mice to germfree recipients phenocopied the higher numbers of ROR gamma t/FoxP3+ cells and reduced susceptibility to colitis in D+ vs. D- recipient mice. 1,25(OH)(2)D treatment of the D- mice beginning at 3 weeks of age did not completely recover ROR gamma t/FoxP3+ T reg cells or the Bacteriodes, Bacteriodes thetaiotaomicron, and Clostridium XIVa numbers to D+ values. Early vitamin D status shapes themicrobiota to optimize the population of colonic ROR gamma t/FoxP3+ T reg cells important for resistance to colitis. |
| 资助项目 | National Institutes of Health[R01AT005378] ; United States Department of Agriculture National Institute of Food[PEN04605-1010021] ; United State Department of Agriculture[2914-38420-21822] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000477807200002 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/8627]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Cantorna, Margherita T. |
| 作者单位 | 1.Penn State Univ, Ctr Mol Immunol & Infect Dis, University Pk, PA 16802 USA 2.Cedars Sinai Med Ctr, Lung Inst, Los Angeles, CA 90048 USA 3.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA 4.Univ Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, CAS Key Lab Magnet Resonance Biol Syst, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cantorna, Margherita T.,Lin, Yang-Ding,Arora, Juhi,et al. Vitamin D Regulates the Microbiota to Control the Numbers of ROR gamma t/FoxP3+Regulatory T Cells in the Colon[J]. FRONTIERS IN IMMUNOLOGY,2019,10:10. |
| APA | Cantorna, Margherita T..,Lin, Yang-Ding.,Arora, Juhi.,Bora, Stephanie.,Tian, Yuan.,...&Patterson, Andrew D..(2019).Vitamin D Regulates the Microbiota to Control the Numbers of ROR gamma t/FoxP3+Regulatory T Cells in the Colon.FRONTIERS IN IMMUNOLOGY,10,10. |
| MLA | Cantorna, Margherita T.,et al."Vitamin D Regulates the Microbiota to Control the Numbers of ROR gamma t/FoxP3+Regulatory T Cells in the Colon".FRONTIERS IN IMMUNOLOGY 10(2019):10. |
入库方式： OAI收割
来源：武汉植物园
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