Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine
文献类型：期刊论文
| 作者 | Zhang, Ya-Nan1,2; Deng, Cheng-Lin2; Li, Jia-Qi1,2; Li, Na1,2; Zhang, Qiu-Yan1,2; Ye, Han-Qing2; Yuan, Zhi-Ming2; Zhang, Bo2 |
| 刊名 | JOURNAL OF VIROLOGY
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 93期号:15页码:16 |
| 关键词 | chikungunya virus alphavirus capsid vaccines |
| ISSN号 | 0022-538X |
| DOI | 10.1128/JVI.00504-19 |
| 英文摘要 | Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes epidemics of debilitating disease worldwide. Currently, there are no licensed vaccines or antivirals available against CHIKV infection. In this study, we generated a novel live attenuated vaccine (LAV) candidate for CHIKV with a complete deficiency of capsid (Delta C-CHIKV). It could propagate in BHK-21 cells, and had antigenic properties similar to those of native CHIKV. Vaccination of either immunocompromised IFNAR(-/-) mice or immunocompetent C57BL/6 mice with a single dose of Delta C-CHIKV conferred complete protection upon challenge with wild-type (WT) CHIKV. Taken together, this vaccine candidate appeared to be safe and efficacious, representing a novel strategy for CHIKV vaccine design. IMPORTANCE Currently, there is no licensed vaccine against CHIKV infection. An ideal CHIKV vaccine should generate an optimal balance between efficacy and safety. Live attenuated vaccines that can elicit strong immune responses often involve a trade-off of reduced safety. Here, a novel live attenuated vaccine candidate for CHIKV lacking the entire capsid gene, Delta C-CHIKV, was developed. It was demonstrated to be genetically stable, highly attenuated, immunogenic, and able to confer complete protection against lethal CHIKV challenge after a single dose of immunization. Such an infectious vaccine candidate devoid of capsid provides a novel strategy for the development of a live attenuated CHIKV vaccine. |
| 资助项目 | National Key Research and Development Program of China[2018YFA0507201] |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000475793200015 |
| 出版者 | AMER SOC MICROBIOLOGY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/8701]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Zhang, Bo |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Ctr Emerging Infect Dis, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ya-Nan,Deng, Cheng-Lin,Li, Jia-Qi,et al. Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine[J]. JOURNAL OF VIROLOGY,2019,93(15):16. |
| APA | Zhang, Ya-Nan.,Deng, Cheng-Lin.,Li, Jia-Qi.,Li, Na.,Zhang, Qiu-Yan.,...&Zhang, Bo.(2019).Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine.JOURNAL OF VIROLOGY,93(15),16. |
| MLA | Zhang, Ya-Nan,et al."Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine".JOURNAL OF VIROLOGY 93.15(2019):16. |
入库方式： OAI收割
来源：武汉植物园
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