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Triterpenoids from the stems and leaves of Schisandra incarnata

文献类型：期刊论文

作者Zhou, Ming2,3; Peng, Xiaogang3; Zhou, Jia3; Liu, Ye2,3; Meng, Xianggao1; Ruan, Hanli3
刊名PHYTOCHEMISTRY
出版日期2020-09-01
卷号177页码:8
关键词Schisandra incarnata Stapf Schisandraceae Triterpenoids Immunosuppressive activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2020.112448
英文摘要Six undescribed triterpenoids, schincarins A-F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B-D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo K alpha irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 mu M, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 mu M, respectively.
资助项目National Natural Science Foundation of China[31770380] ; National Natural Science Foundation of China[21572073] ; National Natural Science Foundation of China[31270394] ; Fundamental Research Funds for the Central Universities[2016YXMS150]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000558604600021
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://202.127.146.157/handle/2RYDP1HH/15585]  
专题中国科学院武汉植物园
通讯作者Ruan, Hanli
作者单位1.Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China
2.Chinese Acad Sci, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 430074, Peoples R China
3.Huazhong Univ Sci & Technol, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Tongji Med Coll, Hangkonglu 13, Wuhan 430030, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Ming,Peng, Xiaogang,Zhou, Jia,et al. Triterpenoids from the stems and leaves of Schisandra incarnata[J]. PHYTOCHEMISTRY,2020,177:8.
APA Zhou, Ming,Peng, Xiaogang,Zhou, Jia,Liu, Ye,Meng, Xianggao,&Ruan, Hanli.(2020).Triterpenoids from the stems and leaves of Schisandra incarnata.PHYTOCHEMISTRY,177,8.
MLA Zhou, Ming,et al."Triterpenoids from the stems and leaves of Schisandra incarnata".PHYTOCHEMISTRY 177(2020):8.

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来源：武汉植物园

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