Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Zhang, Li2,3; Chen, Jungang2; Ke, Chang2; Zhang, Haiwei2; Zhang, Shoujun4; Tang, Wei2; Liu, Chunlan2; Liu, Ge2,3; Chen, Si2,3; Hu, Ao2,3 |
| 刊名 | VIRUSES-BASEL
 |
| 出版日期 | 2020-05-01 |
| 卷号 | 12期号:5页码:12 |
| 关键词 | influenza virus caesalpinia decapetala antiviral extract |
| DOI | 10.3390/v12050557 |
| 英文摘要 | Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there have been no effective drugs as yet to cure all patients infected by influenza viruses. Natural products from plants contain compounds with diverse structures that have the potential to interact with multiple host and virus factors. In this study, we identified the ethanol extract of Caesalpinia decapetala (Roth) Alston (EEC) as an inhibitor against the replication of a panel of influenza A and B viruses both on human pulmonary epithelial A549 and human monocytic U937 cells. The animal study revealed that EEC administration reduces the weight loss and improves the survival rate of mice infected with lethal influenza virus. Also, EEC treatment attenuated lung injury and reduced virus titer significantly. In conclusion, we showed that EEC has antiviral activity both in vitro and in vivo, suggesting that the plant C. decapetala has the potential to be further developed as a resource of new anti-influenza drugs. |
| 资助项目 | Wuhan Applied Basic Research Frontier Program[2019020701011448] |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000565860200074 |
| 出版者 | MDPI |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/15657]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Chen, Xulin |
| 作者单位 | 1.Jinan Univ, Inst Med Microbiol, Guangdong Prov Key Lab Virol, Guangzhou 510630, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 100864, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Li,Chen, Jungang,Ke, Chang,et al. Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo[J]. VIRUSES-BASEL,2020,12(5):12. |
| APA | Zhang, Li.,Chen, Jungang.,Ke, Chang.,Zhang, Haiwei.,Zhang, Shoujun.,...&Chen, Xulin.(2020).Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo.VIRUSES-BASEL,12(5),12. |
| MLA | Zhang, Li,et al."Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo".VIRUSES-BASEL 12.5(2020):12. |
入库方式： OAI收割
来源：武汉植物园
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。