中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo

文献类型:期刊论文

作者Zhang, Li1,4; Chen, Jungang1; Ke, Chang1; Zhang, Haiwei1; Zhang, Shoujun2; Tang, Wei1; Liu, Chunlan1; Liu, Ge1,4; Chen, Si1,4; Hu, Ao1,4
刊名VIRUSES-BASEL
出版日期2020-05-01
卷号12期号:5页码:12
关键词influenza virus caesalpinia decapetala antiviral extract
DOI10.3390/v12050557
英文摘要Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there have been no effective drugs as yet to cure all patients infected by influenza viruses. Natural products from plants contain compounds with diverse structures that have the potential to interact with multiple host and virus factors. In this study, we identified the ethanol extract of Caesalpinia decapetala (Roth) Alston (EEC) as an inhibitor against the replication of a panel of influenza A and B viruses both on human pulmonary epithelial A549 and human monocytic U937 cells. The animal study revealed that EEC administration reduces the weight loss and improves the survival rate of mice infected with lethal influenza virus. Also, EEC treatment attenuated lung injury and reduced virus titer significantly. In conclusion, we showed that EEC has antiviral activity both in vitro and in vivo, suggesting that the plant C. decapetala has the potential to be further developed as a resource of new anti-influenza drugs.
资助项目Wuhan Applied Basic Research Frontier Program[2019020701011448]
WOS研究方向Virology
语种英语
出版者MDPI
WOS记录号WOS:000565860200074
源URL[http://202.127.146.157/handle/2RYDP1HH/15658]  
专题中国科学院武汉植物园
通讯作者Chen, Xulin
作者单位1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 100864, Peoples R China
2.Chinese Acad Sci, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 100864, Peoples R China
3.Jinan Univ, Inst Med Microbiol, Guangdong Prov Key Lab Virol, Guangzhou 510630, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Li,Chen, Jungang,Ke, Chang,et al. Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo[J]. VIRUSES-BASEL,2020,12(5):12.
APA Zhang, Li.,Chen, Jungang.,Ke, Chang.,Zhang, Haiwei.,Zhang, Shoujun.,...&Chen, Xulin.(2020).Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo.VIRUSES-BASEL,12(5),12.
MLA Zhang, Li,et al."Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo".VIRUSES-BASEL 12.5(2020):12.

入库方式: OAI收割

来源:武汉植物园

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