Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC-MS
文献类型：期刊论文
| 作者 | Fan, Minxia1,5,6; Chen, Guilin1,5; Sun, Baoqing2; Wu, Jianlin3; Li, Na3; Sarker, Satyajit D.4; Nahar, Lutfun4; Guo, Mingquan1,5 |
| 刊名 | PHYTOCHEMISTRY REVIEWS
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 19期号:5页码:1231-1261 |
| ISSN号 | 1568-7767 |
| 关键词 | Natural inhibitors Topoisomerases Medicinal plants Bio-affinity ultrafiltration LC-MS |
| DOI | 10.1007/s11101-019-09635-x |
| 英文摘要 | The continuing rise in cancer morbidity and mortality all over the world makes cancer the No. 2 cause of death in humans, posing a major public health challenge. Currently, surgery, radiotherapy, and chemotherapy are the three major approaches to treat cancer. However, the disadvantages of serious side effects, and poor therapeutic effect of the aforementioned methods in many clinical cases have become a burning question to be solved. DNA topoisomerases (Topos) are the key enzymes for DNA replication, transcription, recombination and repair, and have been regarded as target enzymes for some anticancer drugs, leading to the development of some successful anticancer drugs now in clinical use. Moreover, medicinal plants with numerous bioactive compounds are one of the most important sources for the discovery and development of anticancer drugs. In an active effort to search for Topo inhibitors from medicinal plants, affinity selection-ultrafiltration/high performance liquid chromatography-mass spectrometry (AS/UF-LC-MS) is among the most efficient techniques in term of sensitivity, throughput, and wide applicability. This review summarized the most recent advances in screening Topo inhibitors with AS/UF-LC-MS from medicinal plants over the past 15 years, with focus on structures, functions, the mechanisms of action of Topos and the procedures of the AS/UF-LC-MS technology, with an aim to provide comprehensive insights for new drug research and the discovery of more effective leading compounds against Topos. |
| 资助项目 | National Natural Science Foundation of China[81673580] ; Major Project for Special Technology Innovation of Hubei Province[2017AHB054] ; Macao Science and Technology Development Fund[0090/2018/A3] |
| WOS研究方向 | Plant Sciences |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000576826900008 |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/15867]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Guo, Mingquan |
| 作者单位 | 1.Chinese Acad Sci, Sinoafrica Joint Res Ctr, Wuhan 430074, Peoples R China 2.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, State Key Lab Resp Dis,Natl Clin Ctr Resp Dis, Guangzhou, Guangdong, Peoples R China 3.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China 4.Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, Liverpool L3 3AF, Merseyside, England 5.Chinese Acad Sci, Wuhan Bot Garden, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan 430074, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Minxia,Chen, Guilin,Sun, Baoqing,et al. Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC-MS[J]. PHYTOCHEMISTRY REVIEWS,2020,19(5):1231-1261. |
| APA | Fan, Minxia.,Chen, Guilin.,Sun, Baoqing.,Wu, Jianlin.,Li, Na.,...&Guo, Mingquan.(2020).Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC-MS.PHYTOCHEMISTRY REVIEWS,19(5),1231-1261. |
| MLA | Fan, Minxia,et al."Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC-MS".PHYTOCHEMISTRY REVIEWS 19.5(2020):1231-1261. |
入库方式： OAI收割
来源：武汉植物园
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