Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification
文献类型：期刊论文
| 作者 | Seukep, Armel Jackson2,3,4; Kuete, Victor4; Nahar, Lutfun5,6; Sarker, Satyajit D.1; Guo, Mingquan2,3 |
| 刊名 | JOURNAL OF PHARMACEUTICAL ANALYSIS
 |
| 出版日期 | 2020-08-01 |
| 卷号 | 10期号:4页码:277-290 |
| 关键词 | Multidrug-resistant bacteria Efflux pump inhibitors Plant secondary metabolites Edible plants Efflux activity assays |
| ISSN号 | 2095-1779 |
| DOI | 10.1016/j.jpha.2019.11.002 |
| 英文摘要 | The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The major factor in MDR is efflux pump-mediated resistance. A unique pump can make bacteria withstand a wide range of structurally diverse compounds. Therefore, their inhibition is a promising route to eliminate resistance phenomenon in bacteria. Phytochemicals are excellent alternatives as resistance-modifying agents. They can directly kill bacteria or interact with the crucial events of pathogenicity, thereby decreasing the ability of bacteria to develop resistance. Numerous botanicals display noteworthy efflux pumps inhibitory activities. Edible plants are of growing interest. Likewise, some plant families would be excellent sources of efflux pump inhibitors (EPIs) including Apocynaceae, Berberidaceae, Convolvulaceae, Cucurbitaceae, Fabaceae, Lamiaceae, and Zingiberaceae. Easily applicable methods for screening plant-derived EPIs include checkerboard synergy test, berberine uptake assay and ethidium bromide test. In silico high-throughput virtual detection can be evaluated as a criterion of excluding compounds with efflux substrate-like characteristics, thereby improving the selection process and extending the identification of EPIs. To ascertain the efflux activity inhibition, real-time PCR and quantitative mass spectrometry can be applied. This review emphasizes on efflux pumps and their roles in transmitting bacterial resistance and an update plant-derived EPIs and strategies for identification. (C) 2019 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. |
| 资助项目 | Chinese Academy of Sciences (CAS) under CAS President's International Fellowship Initiative (CAS-PIFI) projects[2018PB0089] ; Chinese Academy of Sciences (CAS) under CAS President's International Fellowship Initiative (CAS-PIFI) projects[2019VBA0026] ; Major Project for Special Technology Innovation of Hubei Province[2017AHB054] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000580993400001 |
| 出版者 | ELSEVIER |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/15902]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Guo, Mingquan |
| 作者单位 | 1.Liverpool John Moores Univ, Ctr Nat Prod Discovery, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England 2.Chinese Acad Sci, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, Sino Africa Joint Res Ctr, Wuhan, Peoples R China 4.Univ Dschang, Fac Sci, Dept Biochem, Unit Res Microbiol & Antimicrobial Subst,Lab Canc, Dschang, Cameroon 5.Inst Expt Bot ASCR, Lab Growth Regulators, Slechtitelu 27, Olomouc 78371, Czech Republic 6.Palacky Univ, Slechtitelu 27, Olomouc 78371, Czech Republic |
| 推荐引用方式 GB/T 7714 | Seukep, Armel Jackson,Kuete, Victor,Nahar, Lutfun,et al. Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification[J]. JOURNAL OF PHARMACEUTICAL ANALYSIS,2020,10(4):277-290. |
| APA | Seukep, Armel Jackson,Kuete, Victor,Nahar, Lutfun,Sarker, Satyajit D.,&Guo, Mingquan.(2020).Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification.JOURNAL OF PHARMACEUTICAL ANALYSIS,10(4),277-290. |
| MLA | Seukep, Armel Jackson,et al."Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification".JOURNAL OF PHARMACEUTICAL ANALYSIS 10.4(2020):277-290. |
入库方式： OAI收割
来源：武汉植物园
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