Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
文献类型：期刊论文
| 作者 | Ahn, Matae1; Anderson, Danielle E.1; Zhang, Qian1,2,3; Tan, Chee Wah1; Lim, Beng Lee1; Luko, Katarina1; Wen, Ming1; Chia, Wan Ni1; Mani, Shailendra1; Wang, Loo Chien4 |
| 刊名 | NATURE MICROBIOLOGY
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 4期号:5页码:789-799 |
| ISSN号 | 2058-5276 |
| DOI | 10.1038/s41564-019-0371-3 |
| 英文摘要 | Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked. The important inflammasome sensor, NLR family pyrin domain containing 3 (NLRP3), has been linked to both viral-induced and age-related inflammation. Here, we report significantly dampened activation of the NLRP3 inflammasome in bat primary immune cells compared to human or mouse counterparts. Lower induction of apoptosis-associated speck-like protein containing a CARD (ASC) speck formation and secretion of interleukin-1 beta in response to both 'sterile' stimuli and infection with multiple zoonotic viruses including influenza A virus (-single-stranded (ss) RNA), Melaka virus (PRV3M, double-stranded RNA) and Middle East respiratory syndrome coronavirus (+ssRNA) was observed. Importantly, this reduction of inflammation had no impact on the overall viral loads. We identified dampened transcriptional priming, a novel splice variant and an altered leucine-rich repeat domain of bat NLRP3 as the cause. Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity and unique viral reservoir status. |
| 资助项目 | Singapore National Research Foundation[NRF2012NRF-CRP001-056] ; Singapore National Research Foundation[NRF2016NRF-NSFC002-013] ; New Investigator's Grant from the National Medical Research Council of Singapore[NMRC/BNIG/2040/2015] ; National Natural Science Foundation of China[31621061] ; Young Investigator Grant YIG 2015 (BMRC, A*STAR) ; NMRC MS-CETSA platform grant[MOHIAFCAT2/004/2015] |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000465477000012 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/7259]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Irving, Aaron T.; Wang, Lin-Fa |
| 作者单位 | 1.Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore 2.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Inst Mol & Cellular Biol A STAR, Funct Prote Lab, Singapore, Singapore 5.ASTAR, IMB, Singapore, Singapore 6.ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore |
| 推荐引用方式 GB/T 7714 | Ahn, Matae,Anderson, Danielle E.,Zhang, Qian,et al. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host[J]. NATURE MICROBIOLOGY,2019,4(5):789-799. |
| APA | Ahn, Matae.,Anderson, Danielle E..,Zhang, Qian.,Tan, Chee Wah.,Lim, Beng Lee.,...&Wang, Lin-Fa.(2019).Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.NATURE MICROBIOLOGY,4(5),789-799. |
| MLA | Ahn, Matae,et al."Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host".NATURE MICROBIOLOGY 4.5(2019):789-799. |
入库方式： OAI收割
来源：武汉植物园
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