Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men
文献类型：期刊论文
| 作者 | Ullah, Hamid1; Nabi, Ghulam1,2,3; Zubair, Hira1; Ullah, Rahim1,4; Shahab, Muhammad1 |
| 刊名 | ANDROLOGIA
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 51期号:4页码:9 |
| 关键词 | hypothalamus kisspeptin pituitary reproduction testes |
| ISSN号 | 0303-4569 |
| DOI | 10.1111/and.13219 |
| 英文摘要 | The present study was designed to assess the responsiveness of hypothalamic-pituitary-gonadal axis to kisspeptin administration with increasing age in men. Human kisspeptin-10 was administered in single iv bolus dose (1 mu g/kg BW) to healthy adult, middle and advanced age men. Serial blood samples were collected for 30 min pre- and 120 min post-kisspeptin injection periods at 30-min interval. Analysis of plasma LH by ELISA showed a significant (p < 0.05) increase after kisspeptin-10 administration in all groups, whereas plasma testosterone concentration was significantly elevated (p < 0.05) after kisspeptin-10 injection only in the adult men group. Present results suggest that in men, central hypothalamic-pituitary axis remains active and shows responsiveness to kisspeptin stimulation across life. However, Leydig cell responsiveness to kisspeptin-induced LH decreases with age in men. |
| 资助项目 | Higher Education Commission, Pakistan |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000463161400004 |
| 出版者 | WILEY |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/7154]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Shahab, Muhammad |
| 作者单位 | 1.Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Lab Reprod Neuroendocrinol, Islamabad, Pakistan 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Zhejiang Univ, Childrens Hosp, Sch Med, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ullah, Hamid,Nabi, Ghulam,Zubair, Hira,et al. Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men[J]. ANDROLOGIA,2019,51(4):9. |
| APA | Ullah, Hamid,Nabi, Ghulam,Zubair, Hira,Ullah, Rahim,&Shahab, Muhammad.(2019).Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men.ANDROLOGIA,51(4),9. |
| MLA | Ullah, Hamid,et al."Age-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men".ANDROLOGIA 51.4(2019):9. |
入库方式： OAI收割
来源：武汉植物园
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