Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L
文献类型：期刊论文
| 作者 | Yu, Fan1; Li, Jianlin1; Li, Hongxia1; Tang, Yongkai1; Wang, Meiyao1; Hu, Wei2; Yu, Juhua1 |
| 刊名 | BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
 |
| 出版日期 | 2018-11-02 |
| 卷号 | 32期号:6页码:1440-1446 |
| 关键词 | Common carp glucose serum transcriptome immune response |
| ISSN号 | 1310-2818 |
| DOI | 10.1080/13102818.2018.1534554 |
| 英文摘要 | Glucose metabolism is a key biological process in animals, as it is related to multiple activities including immune response and diseases. In this study, we focused on serum parameter changes and hepatic gene expression to explore the immune response to glucose injection. We performed serum analysis and high-throughput sequencing analysis in the liver of common carp (Cyprinus carpio L). The serum GLU and albumin were up-regulated by glucose injection. The transcriptome analysis showed that the categories of response to external stimulus in GO category, PPAR-signalling pathway, complement and coagulation cascades pathways in KEGG analysis were enriched in genes that were differently expressed between the glucose injection group and the control group. Among these pathways, redox-regulatory protein FAM213A-like, extracellular superoxide dismutase [Cu-Zn]-like and putative natural resistance-associated macrophage protein (NRAMP) were up-regulated by glucose stimulation. The 25-hydroxyvitamin D-1 alpha hydroxylase, vitamin D 25-hydroxylase and natterin-3-like were significantly down-regulated by glucose injection. The present study is the first report of serum and hepatic transcriptome changes in common carp in response to glucose increase in serum. The obtained data provide valuable clues for future efforts into understanding the connection between the energy metabolism and the immune system. |
| 资助项目 | Natural Science Foundation of Jiangsu Province[BK20151104] ; National Natural Science Foundation of China[31402281] ; National Natural Science Foundation of China[31872583] ; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences[2018FB15] ; Science Foundation of Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture[GXKEYLA2016-04] ; Special Fund of Fundamental Scientific Research Business Expense for Central Public Research Institutes[2015JBFR02] |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000461398900011 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/6997]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Yu, Fan; Yu, Juhua |
| 作者单位 | 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resource, Minist Agr, Wuxi, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Fan,Li, Jianlin,Li, Hongxia,et al. Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L[J]. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,2018,32(6):1440-1446. |
| APA | Yu, Fan.,Li, Jianlin.,Li, Hongxia.,Tang, Yongkai.,Wang, Meiyao.,...&Yu, Juhua.(2018).Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L.BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,32(6),1440-1446. |
| MLA | Yu, Fan,et al."Effects of glucose on biochemical immune responses and hepatic gene expression in common carp, Cyprinus carpio L".BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 32.6(2018):1440-1446. |
入库方式： OAI收割
来源：武汉植物园
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