Characterization of a filovirus (Mengla virus) from Rousettus bats in China
文献类型：期刊论文
| 作者 | Yang, Xing-Lou1,2; Tan, Chee Wah2; Anderson, Danielle E.2; Jiang, Ren-Di1,3; Li, Bei1; Zhang, Wei1; Zhu, Yan1; Lim, Xiao Fang2; Zhou, Peng1; Liu, Xiang-Ling1 |
| 刊名 | NATURE MICROBIOLOGY
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 4期号:3页码:390-395 |
| ISSN号 | 2058-5276 |
| DOI | 10.1038/s41564-018-0328-y |
| 英文摘要 | Filoviruses, especially Ebola virus (EBOV) and Marburg virus (MARV), are notoriously pathogenic and capable of causing severe haemorrhagic fever diseases in humans with high lethality(1/2). The risk of future outbreaks is exacerbated by the discovery of other bat-borne filoviruses of wide genetic diversity globally(3-5). Here we report the characterization of a phylogenetically distinct bat filovirus, named Mengla virus (MLAV). The coding-complete genome of MLAV shares 32-54% nucleotide sequence identity with known filoviruses. Phylogenetic analysis places this new virus between EBOV and MARV, suggesting the need for a new genus taxon. Importantly, despite the low amino acid sequence identity (22-39%) of the glycoprotein with other filoviruses, MLAV is capable of using the Niemann-Pick C1 (NPC1) as entry receptor. MLAV is also replication-competent with chimeric MLAV mini-genomes containing EBOV or MARV leader and trailer sequences, indicating that these viruses are evolutionally and functionally closely related. Finally, MLAV glycoprotein-typed pseudo-types transduced cell lines derived from humans, monkeys, dogs, hamsters and bats, implying a broad species cell tropism with a high risk of interspecies spillover transmission. |
| 资助项目 | Chinese Academy of Sciences[XDB29010000] ; Singapore National Research Foundation[NRF2012NRF-CRP001-056] ; Singapore National Research Foundation[NRF2016NRF-NSFC002-013] ; Singapore MINDEF grant[MINDEF-NUS-DIRP/2015/04] ; Chinese Academy of Sciences |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000459201400007 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/6900]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Wang, Lin-Fa; Shi, Zheng-Li |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens, Wuhan, Hubei, Peoples R China 2.Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Guangdong Inst Appl Biol Resources, Guangzhou, Guangdong, Peoples R China 5.Wuhan Univ, Wuhan, Hubei, Peoples R China 6.Yunnan Inst Endem Dis Control & Prevent, Dali, Peoples R China 7.Dali Univ, Dali, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xing-Lou,Tan, Chee Wah,Anderson, Danielle E.,et al. Characterization of a filovirus (Mengla virus) from Rousettus bats in China[J]. NATURE MICROBIOLOGY,2019,4(3):390-395. |
| APA | Yang, Xing-Lou.,Tan, Chee Wah.,Anderson, Danielle E..,Jiang, Ren-Di.,Li, Bei.,...&Shi, Zheng-Li.(2019).Characterization of a filovirus (Mengla virus) from Rousettus bats in China.NATURE MICROBIOLOGY,4(3),390-395. |
| MLA | Yang, Xing-Lou,et al."Characterization of a filovirus (Mengla virus) from Rousettus bats in China".NATURE MICROBIOLOGY 4.3(2019):390-395. |
入库方式： OAI收割
来源：武汉植物园
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