A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans
文献类型：期刊论文
| 作者 | Jiang, Wei1,2,3,4; Wei, Yuehua1,4; Long, Yong1,4,5; Owen, Arthur6; Wang, Bingying1,4; Wu, Xuebing7; Luo, Shuo7; Dang, Yongjun2,3; Ma, Dengke K.1,4 |
| 刊名 | ELIFE
 |
| 出版日期 | 2018-04-17 |
| 卷号 | 7页码:19 |
| ISSN号 | 2050-084X |
| DOI | 10.7554/eLife.35037 |
| 英文摘要 | How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From C. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNA mir-60. Downstream of ISY-1 and mir-60, zip-10 levels rapidly and specifically increase upon transient cold-warming exposure. Prolonged zip-10 up-regulation induces several protease-encoding genes and promotes stress-induced organismic death, or phenoptosis, of C. elegans. zip-10 deficiency confers enhanced resistance to prolonged cold-warming stress, more prominently in adults than larvae. We conclude that the ZIP-10 genetic program mediates cold-warming response and may have evolved to promote wild-population kin selection under resource-limiting and thermal stress conditions. |
| 资助项目 | China Postdoctoral Science Foundation ; National Institute on Aging[R01AG032435] ; National Institute of General Medical Sciences[R01GM117461] ; Pew Charitable Trusts ; American Diabetes Association[1-16-IBS-197] ; Alfred P. Sloan Foundation ; David and Lucile Packard Foundation ; Esther A. and Joseph Klingenstein Fund ; National Heart, Lung, and Blood Institute[R00HL116654] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000458481900001 |
| 出版者 | ELIFE SCIENCES PUBLICATIONS LTD |
| 源URL | [http://202.127.146.157/handle/2RYDP1HH/6722]  |
| 专题 | 中国科学院武汉植物园 |
| 通讯作者 | Ma, Dengke K. |
| 作者单位 | 1.Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA 2.Fudan Univ, Key Lab Metab & Mol Med, Minist Educ, Shanghai, Peoples R China 3.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai, Peoples R China 4.Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94103 USA 5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China 6.Univ Calif Berkeley, Dept Mol Cell Biol, Berkeley, CA 94720 USA 7.MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA |
| 推荐引用方式 GB/T 7714 | Jiang, Wei,Wei, Yuehua,Long, Yong,et al. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans[J]. ELIFE,2018,7:19. |
| APA | Jiang, Wei.,Wei, Yuehua.,Long, Yong.,Owen, Arthur.,Wang, Bingying.,...&Ma, Dengke K..(2018).A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans.ELIFE,7,19. |
| MLA | Jiang, Wei,et al."A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C-elegans".ELIFE 7(2018):19. |
入库方式： OAI收割
来源：武汉植物园
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