A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries
文献类型：期刊论文
| 作者 | Xu, Hongtao7; Gu, Yuang7; Zhang, Shuning2,3,4,7; Xiong, Huan7; Ma, Fei7; Lu, Fengping7; Ji, Qun7; Liu, Lili7; Ma, Peixiang7; Yang, Guang7 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020 |
| 卷号 | 59期号:32页码:13273-13280 |
| 关键词 | C-H CHALCOGENATION CHEMICAL LIBRARIES CATALYZED DIRECT DRUG DISCOVERY BOND FORMATION DISELENIDES ACTIVATION FUNCTIONALIZATION SELENYLATION SELENATION |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202003595 |
| 文献子类 | Article |
| 英文摘要 | Conventional direct C-H selenylation suffers from simple selenation with limited atom economy and complicated reaction system. In this work, we designed benzoselenazolone as a novel bifunctional selenide reagent for both off- and on-DNA C-H selenylation under rhodium(III) catalysis. We show that using benzoselenazolone allowed production of a series of selenylation products containing an adjacent aminoacyl group in a fast and efficient way, with high atom economy. The synthetic application of this method was demonstrated by taking advantage of the amide functionality as a nucleophile, directing group, and amide coupling partner. This work shows great potential in facilitating rapid construction of selenium-containing DNA-encoded chemical libraries (SeDELs), and lays the foundation for the development of selenium-containing drugs. |
| 学科主题 | Chemistry, Multidisciplinary |
| WOS关键词 | benzoselenazolone ; C-H activation ; DNA-encoded library ; rhodium ; selenylation |
| 语种 | 英语 |
| WOS记录号 | WOS:000528892300001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/3526]  |
| 专题 | 生化所2019-2020年发文 |
| 作者单位 | 1.Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA, 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 5.Zhejiang Univ Technol, Inst Drug Dev & Chem Biol, Hangzhou 310014, Peoples R China; 6.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China; 7.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Hongtao,Gu, Yuang,Zhang, Shuning,et al. A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(32):13273-13280. |
| APA | Xu, Hongtao.,Gu, Yuang.,Zhang, Shuning.,Xiong, Huan.,Ma, Fei.,...&,.(2020).A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(32),13273-13280. |
| MLA | Xu, Hongtao,et al."A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.32(2020):13273-13280. |
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