Reversal of nucleobase methylation by dioxygenases
文献类型：期刊论文
| 作者 | Xu, Guo-Liang3,4,5; Bochtler, Matthias1,2; , |
| 刊名 | NATURE CHEMICAL BIOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 16期号:11页码:1160-1169 |
| 关键词 | TET-MEDIATED FORMATION DNA-REPAIR ENZYME MESSENGER-RNA OXIDATIVE DEMETHYLATION HISTONE DEMETHYLATION ACTIVE-DEMETHYLATION ALKYLATION DAMAGE ALKB 5-HYDROXYMETHYLCYTOSINE 5-METHYLCYTOSINE |
| ISSN号 | 1552-4450 |
| DOI | 10.1038/s41589-020-00675-5 |
| 文献子类 | Review |
| 英文摘要 | This Review summarizes the chemical and physical properties of methylated nucleobases in DNA and RNA, proposes a chemical classification of methylation types, and discusses recent advance in demethylation reactions mediated by dioxygenases. The repertoire of nucleobase methylation in DNA and RNA, introduced by chemical agents or enzymes, is large. Most methylation can be reversed either directly by restoration of the original nucleobase or indirectly by replacement of the methylated nucleobase with an unmodified nucleobase. In many direct and indirect demethylation reactions, ALKBH (AlkB homolog) and TET (ten eleven translocation) hydroxylases play a role. Here, we suggest a chemical classification of methylation types. We then discuss pathways for removal, emphasizing oxidation reactions. We highlight the recently expanded repertoire of ALKBH- and TET-catalyzed reactions and describe the discovery of a TET-like protein that resembles the hydroxylases but uses an alternative co-factor and catalyzes glyceryl transfer rather than hydroxylation. |
| 学科主题 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000578829200011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/3539]  |
| 专题 | 生化所2019-2020年发文 |
| 作者单位 | 1.Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland, 2.Int Inst Mol & Cell Biol, Warsaw, Poland; 3.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai, Peoples R China; 4.Chinese Acad Med Sci, Shanghai, Peoples R China; 5.Fudan Univ, Inst Biomed Sci, Lab Med Epigenet, Med Coll, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xu, Guo-Liang,Bochtler, Matthias,,. Reversal of nucleobase methylation by dioxygenases[J]. NATURE CHEMICAL BIOLOGY,2020,16(11):1160-1169. |
| APA | Xu, Guo-Liang,Bochtler, Matthias,&,.(2020).Reversal of nucleobase methylation by dioxygenases.NATURE CHEMICAL BIOLOGY,16(11),1160-1169. |
| MLA | Xu, Guo-Liang,et al."Reversal of nucleobase methylation by dioxygenases".NATURE CHEMICAL BIOLOGY 16.11(2020):1160-1169. |
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