The effects of umbilical cord-derived macrophage exosomes loaded with cisplatin on the growth and drug resistance of ovarian cancer cells
文献类型：期刊论文
| 作者 | Zhang, Xiaohui3; Tang, Meiling3; Guo, Xiaoqing3; Yang, Xiaoqian3; Liu, Li2; Li, Hong1; , |
| 刊名 | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
 |
| 出版日期 | 2020 |
| 卷号 | 46期号:7页码:1150-1162 |
| ISSN号 | 0363-9045 |
| 关键词 | TUMOR-ASSOCIATED MACROPHAGES EXTRACELLULAR VESICLES |
| DOI | 10.1080/03639045.2020.1776320 |
| 文献子类 | Article |
| 英文摘要 | Objective:To assess the feasibility of an exosome-based drug delivery platform for the potent chemotherapeutic agent cisplatin to treat ovarian cancer. Significance:Exosomes have recently been used as drug delivery vehicles because of their natural advantages. Platinum-resistant forms of ovarian cancer require novel drug delivery methods to improve patient outcomes. Methods:We developed and compared different methods of loading exosomes released by mononuclear M1 and M2 macrophages from umbilical cord blood with cisplatin. We characterized the morphology, drug capacity, method of cellular entry, and antitumor efficacy of the exosomesin vitro. Results:Disruption of the exosomal membrane by sonication facilitated a high loading efficiency. Importantly, incorporation of cisplatin into umbilical cord blood-derived M1 macrophage exosomes increased its cytotoxicity 3.3x in drug-resistant A2780/DDP cells and 1.4x in drug-sensitive A2780 cells over chemotherapy alone. Loading of cisplatin into M2 exosomes increased its cytotoxicity by nearly 1.7x in drug-resistant A2780/DDP cells and 1.4x in drug-sensitive A2780 cells. Conclusions:We conclude that cisplatin-loaded M1 exosomes are potentially powerful new tools for the delivery of chemotherapeutics to treat cancers regardless of drug resistance. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS关键词 | Ovarian cancer ; drug resistance ; exosome ; cisplatin ; umbilical cord blood ; macrophages |
| 语种 | 英语 |
| WOS记录号 | WOS:000547046700011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/3540]  |
| 专题 | 生化所2019-2020年发文 |
| 作者单位 | 1.Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China, 2.Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai, Peoples R China; 3.Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, 2699 West Gaoke Rd, Shanghai 200092, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaohui,Tang, Meiling,Guo, Xiaoqing,et al. The effects of umbilical cord-derived macrophage exosomes loaded with cisplatin on the growth and drug resistance of ovarian cancer cells[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,2020,46(7):1150-1162. |
| APA | Zhang, Xiaohui.,Tang, Meiling.,Guo, Xiaoqing.,Yang, Xiaoqian.,Liu, Li.,...&,.(2020).The effects of umbilical cord-derived macrophage exosomes loaded with cisplatin on the growth and drug resistance of ovarian cancer cells.DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,46(7),1150-1162. |
| MLA | Zhang, Xiaohui,et al."The effects of umbilical cord-derived macrophage exosomes loaded with cisplatin on the growth and drug resistance of ovarian cancer cells".DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 46.7(2020):1150-1162. |
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