中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

文献类型:期刊论文

作者Zhang, Hong9,10; Wang, Zheng10; Lou, Jizhong9; Ji, Xiong8; Li, Pilong7; Liu, Cong6; Lou, Jizhong5; Wen, Wenyu3,4; Xiao, Yue2; Zhu, Xueliang2
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2020
卷号63期号:7页码:953-985
ISSN号1674-7305
关键词ASYMMETRIC CELL-DIVISION AMYOTROPHIC-LATERAL-SCLEROSIS NUCLEAR IMPORT RECEPTOR CHROME SHADOW DOMAIN RNA-BINDING PROTEINS PRION-LIKE DOMAINS STRESS GRANULES SPINDLE ORIENTATION REPEAT EXPANSION SELF-RENEWAL
DOI10.1007/s11427-020-1702-x
文献子类Review
英文摘要Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking and membrane contactmediated inter-organelle interactions, have been extensively characterized. However, the molecular details of the assembly and functions of membraneless compartments remain elusive. Mounting evidence has emerged recently that a large number of membraneless compartments, collectively called biomacromolecular condensates, are assembled via liquid-liquid phase separation (LLPS). Phase-separated condensates participate in various biological activities, including higher-order chromatin organization, gene expression, triage of misfolded or unwanted proteins for autophagic degradation, assembly of signaling clusters and actin- and microtubule-based cytoskeletal networks, asymmetric segregations of cell fate determinants and formation of pre- and post-synaptic density signaling assemblies. Biomacromolecular condensates can transition into different material states such as gel-like structures and solid aggregates. The material properties of condensates are crucial for fulfilment of their distinct functions, such as biochemical reaction centers, signaling hubs and supporting architectures. Cells have evolved multiple mechanisms to ensure that biomacromolecular condensates are assembled and disassembled in a tightly controlled manner. Aberrant phase separation and transition are causatively associated with a variety of human diseases such as neurodegenerative diseases and cancers. This review summarizes recent major progress in elucidating the roles of LLPS in various biological pathways and diseases.
学科主题Biology
WOS关键词phase separation ; phase transition ; transcription ; asymmetric division ; postsynaptic density ; autophagy
语种英语
WOS记录号WOS:000540549400002
版本出版稿
源URL[http://202.127.25.143/handle/331003/3544]  
专题生化所2019-2020年发文
作者单位1.Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Clear Water Bay,Kowloon, Hong Kong, Peoples R China,
2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China;
3.Fudan Univ, MOE Frontiers Ctr Brain Sci, Sch Basic Med Sci, Inst Biomed Sci, Shanghai 200032, Peoples R China;
4.Fudan Univ, State Key Lab Med Neurobiol, Sch Basic Med Sci, Inst Biomed Sci, Shanghai 200032, Peoples R China;
5.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China;
6.Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai 201210, Peoples R China;
7.Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Beijing Frontier Res Ctr Biol Struct, Tsinghua Peking Joint Ctr Life Sci,Sch Life Sci, Beijing 100084, Peoples R China;
8.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Life Sci, Key Lab Cell Proliferat & Differentiat,Minist Edu, Beijing 100871, Peoples R China;
9.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China;
10.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China;
推荐引用方式
GB/T 7714
Zhang, Hong,Wang, Zheng,Lou, Jizhong,et al. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases[J]. SCIENCE CHINA-LIFE SCIENCES,2020,63(7):953-985.
APA Zhang, Hong.,Wang, Zheng.,Lou, Jizhong.,Ji, Xiong.,Li, Pilong.,...&,.(2020).Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases.SCIENCE CHINA-LIFE SCIENCES,63(7),953-985.
MLA Zhang, Hong,et al."Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases".SCIENCE CHINA-LIFE SCIENCES 63.7(2020):953-985.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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