Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
文献类型:期刊论文
作者 | Zhang, Hong9,10; Wang, Zheng10; Lou, Jizhong9; Ji, Xiong8; Li, Pilong7; Liu, Cong6; Lou, Jizhong5; Wen, Wenyu3,4; Xiao, Yue2; Zhu, Xueliang2 |
刊名 | SCIENCE CHINA-LIFE SCIENCES |
出版日期 | 2020 |
卷号 | 63期号:7页码:953-985 |
ISSN号 | 1674-7305 |
关键词 | ASYMMETRIC CELL-DIVISION AMYOTROPHIC-LATERAL-SCLEROSIS NUCLEAR IMPORT RECEPTOR CHROME SHADOW DOMAIN RNA-BINDING PROTEINS PRION-LIKE DOMAINS STRESS GRANULES SPINDLE ORIENTATION REPEAT EXPANSION SELF-RENEWAL |
DOI | 10.1007/s11427-020-1702-x |
文献子类 | Review |
英文摘要 | Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking and membrane contactmediated inter-organelle interactions, have been extensively characterized. However, the molecular details of the assembly and functions of membraneless compartments remain elusive. Mounting evidence has emerged recently that a large number of membraneless compartments, collectively called biomacromolecular condensates, are assembled via liquid-liquid phase separation (LLPS). Phase-separated condensates participate in various biological activities, including higher-order chromatin organization, gene expression, triage of misfolded or unwanted proteins for autophagic degradation, assembly of signaling clusters and actin- and microtubule-based cytoskeletal networks, asymmetric segregations of cell fate determinants and formation of pre- and post-synaptic density signaling assemblies. Biomacromolecular condensates can transition into different material states such as gel-like structures and solid aggregates. The material properties of condensates are crucial for fulfilment of their distinct functions, such as biochemical reaction centers, signaling hubs and supporting architectures. Cells have evolved multiple mechanisms to ensure that biomacromolecular condensates are assembled and disassembled in a tightly controlled manner. Aberrant phase separation and transition are causatively associated with a variety of human diseases such as neurodegenerative diseases and cancers. This review summarizes recent major progress in elucidating the roles of LLPS in various biological pathways and diseases. |
学科主题 | Biology |
WOS关键词 | phase separation ; phase transition ; transcription ; asymmetric division ; postsynaptic density ; autophagy |
语种 | 英语 |
WOS记录号 | WOS:000540549400002 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3544] |
专题 | 生化所2019-2020年发文 |
作者单位 | 1.Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Clear Water Bay,Kowloon, Hong Kong, Peoples R China, 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 3.Fudan Univ, MOE Frontiers Ctr Brain Sci, Sch Basic Med Sci, Inst Biomed Sci, Shanghai 200032, Peoples R China; 4.Fudan Univ, State Key Lab Med Neurobiol, Sch Basic Med Sci, Inst Biomed Sci, Shanghai 200032, Peoples R China; 5.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China; 6.Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai 201210, Peoples R China; 7.Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Beijing Frontier Res Ctr Biol Struct, Tsinghua Peking Joint Ctr Life Sci,Sch Life Sci, Beijing 100084, Peoples R China; 8.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Life Sci, Key Lab Cell Proliferat & Differentiat,Minist Edu, Beijing 100871, Peoples R China; 9.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China; 10.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China; |
推荐引用方式 GB/T 7714 | Zhang, Hong,Wang, Zheng,Lou, Jizhong,et al. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases[J]. SCIENCE CHINA-LIFE SCIENCES,2020,63(7):953-985. |
APA | Zhang, Hong.,Wang, Zheng.,Lou, Jizhong.,Ji, Xiong.,Li, Pilong.,...&,.(2020).Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases.SCIENCE CHINA-LIFE SCIENCES,63(7),953-985. |
MLA | Zhang, Hong,et al."Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases".SCIENCE CHINA-LIFE SCIENCES 63.7(2020):953-985. |
入库方式: OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。