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FoxP3 in T-reg cell biology: a molecular and structural perspective

文献类型：期刊论文

作者Deng, G.3; Song, X.2; Greene, M. I.1; ,
刊名CLINICAL AND EXPERIMENTAL IMMUNOLOGY
出版日期2020
卷号199期号:3页码:255-262
ISSN号0009-9104
关键词TRANSCRIPTION FACTOR FOXP3 TARGET GENES PROTEIN STABILITY DOMAIN ALPHA DIFFERENTIATION TRANSPLANTATION AUTOIMMUNITY DEACETYLASES
DOI10.1111/cei.13357
文献子类Review
英文摘要Regulatory T cells (T-regs) are specialized in immune suppression and play a dominant role in peripheral immune tolerance. T-reg cell lineage development and function maintenance is determined by the forkhead box protein 3 (FoxP3) transcriptional factor, whose activity is fine-tuned by its post-translational modifications (PTMs) and interaction partners. In this review, we summarize current studies in the crystal structures, the PTMs and interaction partners of FoxP3 protein, and discuss how these insights may provide a roadmap for new approaches to modulate T-reg suppression, and new therapies to enhance immune tolerance in autoimmune diseases.
学科主题Immunology
WOS关键词allosteric modifiers ; FoxP3 ; protein interactions ; post-translational modifications ; regulatory T cells
语种英语
WOS记录号WOS:000513952100006
版本出版稿
源URL[http://202.127.25.143/handle/331003/3566]  
专题生化所2019-2020年发文
作者单位1.Univ Penn, Perelman Sch Med, Dept Pathol, Lab Med, Philadelphia, PA USA; Peking Univ, 252 John Morgan Bldg, 38 Xue Yuan Rd, Philadelphia, PA 19104 USA,
2.Chinese Acad Sciences, Inst Biochem,CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol,Cell Biol, Shanghai, Shanghai, Peoples R China;
3.Peking Univ, Sch Basic Med Sciences, Dept Immunol, Beijing, Beijing, Peoples R China;
推荐引用方式
GB/T 7714		 Deng, G.,Song, X.,Greene, M. I.,et al. FoxP3 in T-reg cell biology: a molecular and structural perspective[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY,2020,199(3):255-262.
APA Deng, G.,Song, X.,Greene, M. I.,&,.(2020).FoxP3 in T-reg cell biology: a molecular and structural perspective.CLINICAL AND EXPERIMENTAL IMMUNOLOGY,199(3),255-262.
MLA Deng, G.,et al."FoxP3 in T-reg cell biology: a molecular and structural perspective".CLINICAL AND EXPERIMENTAL IMMUNOLOGY 199.3(2020):255-262.

入库方式： OAI收割

来源：上海生物化学与细胞生物学研究所

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