Development and Application of Base Editors
文献类型：期刊论文
| 作者 | Yang, Bei4; Yang, Li2,3; Chen, Jia2; Chen, Jia1; , |
| 刊名 | CRISPR JOURNAL
 |
| 出版日期 | 2019 |
| 卷号 | 2期号:2页码:91-104 |
| 关键词 | CYTOSINE DEAMINATION DIRECTED EVOLUTION DNA-POLYMERASES HUMAN CANCERS GENOMIC DNA CRISPR REPAIR STRAND PATHWAY APOBEC |
| ISSN号 | 2573-1599 |
| DOI | 10.1089/crispr.2019.0001 |
| 文献子类 | Review |
| 英文摘要 | Base editing is emerging as a potent new strategy to achieve precise gene editing. By combining different nucleobase deaminases with Cas9 or Cpf1 proteins, several base editors have recently been developed to achieve targeted base conversions in different genomic contexts. Importantly, base editors have been successfully applied in animals, plants, and bacteria to induce precise substitutions at the single-base level with high efficiency. In this review, we summarize recent progress in the development and application of base editors and discuss some of the future directions of the technology. |
| 学科主题 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000466792400008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/3572]  |
| 专题 | 生化所2019-2020年发文 |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China, 2.Chinese Acad Sci, CAS Key Lab Computat Biol, CAS Max Planck Gesell Partner Inst Computat Biol, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China; 4.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Bei,Yang, Li,Chen, Jia,et al. Development and Application of Base Editors[J]. CRISPR JOURNAL,2019,2(2):91-104. |
| APA | Yang, Bei,Yang, Li,Chen, Jia,Chen, Jia,&,.(2019).Development and Application of Base Editors.CRISPR JOURNAL,2(2),91-104. |
| MLA | Yang, Bei,et al."Development and Application of Base Editors".CRISPR JOURNAL 2.2(2019):91-104. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。