Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice
文献类型：期刊论文
| 作者 | Zhang, Xue3,4; Li, Xiaojun3,4; Hu, Pei2; Zhang, Xiaorui1; , |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2020 |
| 卷号 | 240页码:116357 |
| 关键词 | GUT MICROBIOTA INDUCED OBESITY CALORIE RESTRICTION POLYSACCHARIDES OLIGOSACCHARIDES POLYMERIZATION CONSTITUENTS INFLAMMATION PERFORMANCE OVERWEIGHT |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2020.116357 |
| 文献子类 | Article |
| 英文摘要 | A neutral polysaccharide (LCPS) was obtained from Lobelia chinensis via hot water extraction and ethanol precipitation. After separation and purification, the homogeneous polysaccharide was obtained with a molecular weight of 2.6x10(3) Da. The chemical composition of the extracted polysaccharide contains fructose and glucose with protein-free identified by gas chromatography-mass spectrometer (GC-MS) method. Chemical structure of LCPS was indicated by nuclear magnetic resonance (NMR) spectroscopy. Data indicated that LCPS was an inulintype fructan with alpha-D-Glcp-(1 ->[1)-beta-D-Fruf-(2](15) linkage. LCPS intake reduced at significant level high fat diet (HFD)-induced body weight gain, liver weight, total cholesterol and triglyceride in serum and hepatic tissue, respectively. The lipid droplet accumulation in hepatic tissue was similar between lean and LCPS groups lower than in HFD-induced mice from tissue section staining results. Together, polysaccharides from Lobelia chinensis could be a new source of natural anti-obesity agent against obesity with potential value in the manufacturing supplements and drugs. |
| 学科主题 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS关键词 | Lobelia chinensis Lour polysaccharides ; anti-obesity ; chemical structure ; inulin-type fructan ; high fat diet-induced mice |
| 语种 | 英语 |
| WOS记录号 | WOS:000537314900013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/3582]  |
| 专题 | 生化所2019-2020年发文 |
| 作者单位 | 1.CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China, 2.Chinese Acad Sci, Shanghai Inst Mat Medica, Shanghai, Peoples R China; 3.Yangzhou Univ, Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China; 4.Yangzhou Univ, Inst Translat Med, Med Coll, Yangzhou 225001, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Xue,Li, Xiaojun,Hu, Pei,et al. Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice[J]. CARBOHYDRATE POLYMERS,2020,240:116357. |
| APA | Zhang, Xue,Li, Xiaojun,Hu, Pei,Zhang, Xiaorui,&,.(2020).Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice.CARBOHYDRATE POLYMERS,240,116357. |
| MLA | Zhang, Xue,et al."Chemical structure elucidation of an inulin-type fructan isolated from Lobelia chinensis lour with anti-obesity activity on diet-induced mice".CARBOHYDRATE POLYMERS 240(2020):116357. |
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