Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies
文献类型：期刊论文
| 作者 | Jiang, Yi-Zhou2; Ma, Ding2; Hu, Xin2; Xiao, Yi2; Yu, Ke-Da2; Liu, Yi-Rong2; Yao, Ling2; Zuo, Wen-Jia2; Zhao, Shen2; Gong, Yue2 |
| 刊名 | CANCER CELL
 |
| 出版日期 | 2019 |
| 卷号 | 35期号:3页码:428-+ |
| ISSN号 | 1535-6108 |
| DOI | 10.1016/j.ccell.2019.02.001 |
| 文献子类 | Article |
| 英文摘要 | We comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465 primary triplenegative breast cancer (TNBC). PIK3CA mutations and copy-number gains of chromosome 22q11 were more frequent in our Chinese cohort than in The Cancer Genome Atlas. We classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune-suppressed, and (4) mesenchymal-like. Putative therapeutic targets or biomarkers were identified among each subtype. Importantly, the LAR subtype showed more ERBB2 somatic mutations, infrequent mutational signature 3 and frequent CDKN2A loss. The comprehensive profile of TNBCs provided here will serve as a reference to further advance the understanding and precision treatment of TNBC. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | COPY-NUMBER ALTERATION ; MUTATIONAL PROCESSES ; SOMATIC MUTATIONS ; GENE ; SIGNATURES ; DISCOVERY ; TUMORS ; IDENTIFICATION ; DEFICIENCY ; PATTERNS |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000461697400010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/486]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Roswell Pk Canc Inst, Div Breast Surg, Dept Surg Oncol, Buffalo, NY 14263 USA; 2.Fudan Univ, Precis Canc Med Ctr, Dept Breast Surg, Shanghai Canc Ctr, 270 Dongan Rd, Shanghai 200032, Peoples R China; 3.Fudan Univ, Sch Life Sci & Human Phenome Inst, State Key Lab Genet Engn, 2005 Songhu Rd, Shanghai 200438, Peoples R China; 4.Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200032, Peoples R China; 5.Chinese Natl Human Genome Ctr Shanghai CHGC, Shanghai MOST Key Lab Hlth & Dis Genom, 250 Bibo Rd, Shanghai 201203, Peoples R China; 6.SITI, 250 Bibo Rd, Shanghai 201203, Peoples R China; 7.Chinese Acad Sci, SARI Ctr Stem Cell & Nanomed, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China; 8.Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA; 9.Univ Texas Hlth Sci Ctr San Antonio, Div Hematol Oncol, San Antonio, TX 78284 USA; 10.Genentech Inc, Dept Bioinformat & Computat Biol, 1 DNA Way, San Francisco, CA 94080 USA; |
| 推荐引用方式 GB/T 7714 | Jiang, Yi-Zhou,Ma, Ding,Hu, Xin,et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies[J]. CANCER CELL,2019,35(3):428-+. |
| APA | Jiang, Yi-Zhou.,Ma, Ding.,Hu, Xin.,Xiao, Yi.,Yu, Ke-Da.,...&,.(2019).Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.CANCER CELL,35(3),428-+. |
| MLA | Jiang, Yi-Zhou,et al."Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies".CANCER CELL 35.3(2019):428-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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